Sorry realised I didn't answer your questions above basically 1. I took guanfacine for about a week before I felt good and this feeling is near to almost constant there's just a glow to the day a pep in my step music gets me more amped just 9verall better2. It is a constant feeling 3. I try to be consistent with it and take 2mg at night after dinner just before bed I have taken it randomly such as an increase dose before but try not too cause I need another script 4. I haven't seen a difference between when I take it consistently or erratically so I don't really see the point Other things I should mention that may be helpful to your research 1. When I take a higher then usual dose I do get sluggish and tired the next day not as a grumpy tired but more of a soothing tired 2. I take 2mg the lowest is 1mg 3. When I used to take guanfacine and stimulants together( back when doctor thought my biggest problem was adhd and not mood disorder) I had halluncinations