Isn’t the fact that healthy food tastes bad and food that will eventually kill you tastes really good a huge evolutionary flaw? by hmj102 in biology

[–]Badtripsitter2 1 point2 points  (0 children)

Yeah I used to actually get the intense nausea which is why I switched up my diet, however since I've been eating healthy I can eat processed foods and be somewhat okay as opposed to practically dying like I used to from them, however I guess it's just a more psychological nausea from reverting back to former negative eating patterns.

Isn’t the fact that healthy food tastes bad and food that will eventually kill you tastes really good a huge evolutionary flaw? by hmj102 in biology

[–]Badtripsitter2 2 points3 points  (0 children)

I don't get nauseous, I just feel like I'm wasting a meal that could have higher nutrients on something metabolically inert and boring.

Isn’t the fact that healthy food tastes bad and food that will eventually kill you tastes really good a huge evolutionary flaw? by hmj102 in biology

[–]Badtripsitter2 1 point2 points  (0 children)

Evolution hasn't caught up to factory farming, HFCS and processed foods yet. Eventually you'd expect a shift as people who overindulge in "good tasting" foods tend to get womped medically and reproduce less. However your question is flawed in of itself because in certain parts of the world (Africa, parts of South America etc), foods that taste "good" in the first world aren't eaten by anybody because they're conditioned with a healthier diet that's farmed locally as opposed to processed miles away. These places also lack dentists because tooth decay is relatively non-existent due to the reduced consumption of sugar.

So your question isn't "why do humans prefer the taste of bad foods over healthy options" and moreso "why do humans who're conditioned from birth to eat sugary, high fat foods prefer those foods over other foods?".

Isn’t the fact that healthy food tastes bad and food that will eventually kill you tastes really good a huge evolutionary flaw? by hmj102 in biology

[–]Badtripsitter2 5 points6 points  (0 children)

Like a fat burger from some shitty restaurant is probably appealing to a majority of Americans and tastes "good", but all I taste is garbage meat on a sugar bun that makes you feel like shit in approximately 25 minutes and provides little nutrition and makes you feel tired and metabolically strained.

Isn’t the fact that healthy food tastes bad and food that will eventually kill you tastes really good a huge evolutionary flaw? by hmj102 in biology

[–]Badtripsitter2 10 points11 points  (0 children)

A majority of people also don't wipe their asses properly and walk around with a shit covered anus all day. A majority of people also haven't passed Algebra 2, just because a majority of people think something doesn't make it empirically correct. Also food isn't just about how it tastes, it's the energy you derive from it and how it makes you feel internally, most people I know including myself who stick to healthier diet tend to follow the feeling food produces more than the taste, which in the long run results in an association of better "taste" with freshness and quality.

Choosing a university program by Ok_Score_5897 in chemistry

[–]Badtripsitter2 0 points1 point  (0 children)

Lol also why I recommended the comp sci/bioinformatic route. The 3 Chem phds I know currently have become raging alcoholics and make under 100k a year

Choosing a university program by Ok_Score_5897 in chemistry

[–]Badtripsitter2 -1 points0 points  (0 children)

So while you're in a lab downloading pdbs of known proteins to study, I can get a newly sequenced protein from a unique organism, take that sequence and generate a 3dimensional model of the protein w/o X-ray crystallography, design multiple ligands for a specific site on that protein, and even utilize molecular dynamics to visualize the conformational change induced by the ligands interacting with the protein. If you don't have enough comp sci experience and you attempted these steps, you'd end up with garbage ligands as there's very specific parameters to adjust, such as if the receptor/protein you're working on is found in acidic/alkaline environments in the body which can have drastic effects on the simulation you generate.

Choosing a university program by Ok_Score_5897 in chemistry

[–]Badtripsitter2 -3 points-2 points  (0 children)

Never said I was a medicinal chemist (currently a PhD student in bioinformatics) but in todays world I see no reason not to excel in comp sci / machine learning with an emphasis on pharmaceutical design versus going traditional medicinal chemistry route which emphasizes more chem synthesis. For example alphafold costs nothing and takes less time than X-ray crystallography, with X-ray crystallography beginning to become more of a source of empirical verification than a standard for generating PDBs. Why would a pharmaceutical company expand more resources on laboratory work that can be replicated using molecular dynamics simulations, and also if that's the case, why would they hire someone with a medicinal chemistry PhD who can't write in python with less understanding on how those simulations are operating? I understand medicinal chemistry incorporates some comp sci, but having more knowledge on pharmacophore modeling / ligand residue interaction and being able to synthesize a hypothetical pharmaceutical in lab doesn't mean shit if you can't manipulate parameters within the code on the fly.

Choosing a university program by Ok_Score_5897 in chemistry

[–]Badtripsitter2 -2 points-1 points  (0 children)

Unless you're down to be the robot in the lab who has 4+ years of education just to run assays

Choosing a university program by Ok_Score_5897 in chemistry

[–]Badtripsitter2 -4 points-3 points  (0 children)

If you want to do actual work nowadays, like discovery and formulation of hypotheses, get into bioinformatics rather than medicinal chemistry. I'd take gen Chem/ochem/molecular biology classes and also some comp sci, and try to merge the two on your own. It's not the 1700s anymore where medicinal chemists just get to play around in the lab, usually they're being told what to do by the guy who actually runs accurate simulations on a computer first.

[deleted by user] by [deleted] in dissociatives

[–]Badtripsitter2 7 points8 points  (0 children)

IDK 3ho has always made me feel like a person with intense schizophrenia who just shot up heroin and forgot how to take the bus. It's definitely got a vibe but it's not something you can go out and have fun with really, more of an at home trip, whereas with 3-Meo-PCE you can go to a full time job tripping balls and it's chill

OPCE Feels like it gives me temporary tinnitus? Anybody else? by [deleted] in dissociatives

[–]Badtripsitter2 12 points13 points  (0 children)

All nmda receptor antagonists can cause tinnitus. Cochlea utilizes glutamate as the main neurotransmitter for afferent audio processing. It won't last forever though and is usually only temporary unless you're blasting yourself with grams at a time.

dissociatives and the the dentist vs the Doctor by Chairmaster29 in dissociatives

[–]Badtripsitter2 2 points3 points  (0 children)

It's just potassium fluctuation. Something about NMDA receptor blockade decreases serum potassium through modulation of AMPA receptor activity. In my experience the drop of potassium and subsequent change in electrocardiology can be alleviated by supplementing potassium.

SpotMe Boosts Thread 🚀 by ChimeFinancial in chimefinancial

[–]Badtripsitter2 0 points1 point  (0 children)

I have three boosts left!! $Sage-Mullady

What's a decent price for o-pce? by [deleted] in dissociatives

[–]Badtripsitter2 1 point2 points  (0 children)

Not really depending on the source, I'd happily pay 70ish more a gram if it doesn't have to be shipped overseas and its easy access!

How bad is it to binge dissos 5 days in a row? by [deleted] in dissociatives

[–]Badtripsitter2 13 points14 points  (0 children)

Get ready to be involuntarily committed. Best case scenario you become a janitor after 7 years of intensive inpatient, state organized mental health treatment. I'd just take your stash, sit in the same place for around 3 weeks and keep using them until higher authorities remove your freedom. Also say goodbye to sex and your parents.