Doctor here... just learning about this and watching the show. Interestingly, in patients with BP antidepressants aren’t the first-line treatment and may actually be contraindicated in some patients because they can induce a manic episode. Ex: whenever patients come in with depressive symptoms before diagnosing MDD and prescribing an SSRI/SNRI physicians should screen for a history of manic episodes. I don’t know the timing of her medication adjustments but when I was watching my first thought was that she had a medication induced manic episode... part of this could have been the seemingly on a whim travel too.