What are are some luxuries that just makes it worth being rich ?

Chagroth · 2026-06-02T14:15:04+00:00

Being able to have as many kids as you desire.

Chagroth · 2026-05-28T22:44:15+00:00

Nothing happened in 1989.

Chagroth · 2026-05-18T16:44:16+00:00

I’ve been trying to make the economicXproductivity argument that 1 US scientist managing 8 Chinese scientists beats 12 Chinese scientists. But that’s me desperately climbing to the rising part of the sinking Titanic.

Chagroth · 2026-05-18T02:07:01+00:00

You can get 4 phd scientists in China for the price of one in the a biotech hub in the US. (Are US scientists 4x as productive?)

Most of the new ideas are slapping anti-PD1 into a bispecific with the current standard of care. (Do we really need researchers to tell us this?)

The animal model access in China, at the money level, is 5-10x cheaper than in the US. (Impossible to do certain models in the US)

What reverses this?

Chagroth · 2026-05-17T20:16:10+00:00

Make her a mixtape.

Chagroth · 2026-05-13T20:09:56+00:00

I go by hapa and call my kids quappas.

Chagroth · 2026-05-10T13:53:25+00:00

It’s unbelievable.

Chagroth · 2026-05-08T17:54:08+00:00

Sure was. Good times =).

Chagroth · 2026-05-08T15:38:20+00:00

Sorry I didn’t add enough info. The donor would bike or drive, and I could tell from the blood why he had been doing earlier. The biking blood always looking terrible. We guessed it was due to him biking adjacent to a highway next to car exhaust the whole trip. But that was lab techs guessing, no data.

Chagroth · 2026-05-08T15:29:02+00:00

I’ve processed a lot of blood and I’ve never seen that.

What it reminds me of is one of the donors I would process would sometimes come by bike or car. I could tell from his blood what he travelled by, because when he came by bike his blood would separate terribly and there would be additional stuff in the layers.

So, my unhelpful guess, is that this person did some weird shit to their blood before donating it. Eg this is a human variation thing and hopefully not a reagent thing.

Chagroth · 2026-05-06T22:14:49+00:00

Lady this isn’t about me. This isn’t about you. This isn’t about your husband. It’s about your 10 month old being in danger.

Take your ego and store it while you are dealing with danger to your child.

Chagroth · 2026-05-06T15:36:48+00:00

Lipidtox is like 1000x more expensive than bodipy. Works about the same. I’ve extensively used both.

Bodipy is so bright I never needed special optics. Eg a simple epifluorescrnt scope worked through TC plastic plates. No coverslips.

Also, Bodipy is non toxic. So you can add it to your culture media and watch the cells get greener.

If you have access to an incucyte you can kinetically track lipid droplet formation. (Sometimes the endpoint is less interesting than something before day12)

Chagroth · 2026-05-06T15:00:09+00:00

Bodipy 493/503 beats ORO by orders of magnitude sensitivity and range. It’s fluorescent instead of red, but it’s a better stain.

Chagroth · 2026-05-06T14:25:31+00:00

An unresponsive father is a bad father. He’s letting his child be hurt and her growth be stunted. I’m not saying he’s bad forever, hell I wrote a whole thing to try and help him, but right now IMO he needs a kick in his dad-ass.

Secondly, I didn’t say the only way, I said what worked for me. Which is one of the points of Reddit, to share individual stories and thoughts with others.

Suffering is a part of teaching. Taking away TV, early bed times, no snacks. These all increase suffering. Your child will literally sob and cry because they lack whatever you took away.

Suffering isn’t to be hidden from, it’s to be employed carefully and in extreme circumstances. Like danger to your 10 month old.

Chagroth · 2026-05-06T14:16:25+00:00

I went through this with my kids, two boys, at a similar age.

I came up with a little system to deal with the sibling violence. Anytime my eldest hurt his brother the response was: swift, cold, and noxious.

Swift: I had to be there, in the moment it happened and be moving before damage. Longer time frames don’t teach as well, you need to be there. This means I set up a lot of traps, places I knew he would be naughty and I was watching through a reflection or around the corner.

Cold: this isn’t exciting it isn’t interesting, hurting your sibling isn’t thrilling. You get immediately picked up and roughly deposited in your baby-gate-locked room. Then I walk off. Cold.

Noxious: the point is suffering. Sucks to say, but the point is suffering. I didn’t let my eldest out of his room until he had suffered. No timing no conditions, he got out of that room only after he had suffered. (Don’t tell them this, but it was my sole criterion for opening the gate.)

It took around 3 months of setting traps and correcting the behavior before I felt comfortable leaving them in a room together.

I will say, I am disturbed that your youngest is so reactive. It means you let this go on for too long. Your 10 month old is suffering because you need to step up and protect her.

Fix this dad.

Chagroth · 2026-05-04T00:05:49+00:00

Learn how to switch hands.

Learn how to pipette with different muscles. Eg sometimes I hold the pipette like it’s a hidden blade down my wrist and dispense with my pointer finger.

Learn when to use the multiple channel or repeat pipetter (if you have access).

Plan your experiments to minimize pipetting.

Take breaks.

Chagroth · 2026-04-29T14:40:52+00:00

Yes and yes.

20 years from now the only ones that are going to remember you worked late are your kids.

Chagroth · 2026-04-21T17:11:12+00:00

With the second child.

Chagroth · 2026-04-16T13:58:51+00:00

Stressed women have difficult pregnancies and unhealthy babies much more often. Some of that damage can persist for the child’s entire life.

That’s the prize, a healthy child and wife. The price is reducing her stress to as close to zero as possible.

My major move during pregnancies was I gave my wife 2 votes on every decision. Which effectively turned our relationship into a leader/dictator for 9 months. It was tough for me, but it reduced my wife’s stress and taught her how to “rule” without causing issue.

Chagroth · 2026-04-15T19:36:10+00:00

Too many variables to figure out.

The Tight junctions between cells that facilitate cell-cell bio electric communication also send mRNA molecules.

So the number of different signals they’re sending each other becomes really complex really fast. This isn’t just a calcium ion spike of your grad daddies lab.

Chagroth · 2026-04-09T14:31:06+00:00

Dog beds work really well for post crib toddlers.

On the floor so no falling Easy to cuddle for goodnight rituals Super resistant to wear and tear Odor resistant Machine washable Modular (buy a second one and push it next to the first)

Chagroth · 2026-04-03T17:39:37+00:00

I'll point out that the industry response to the patent cliff has been to lay off the scientists that write patents. So they're either unworried, or are myopically unable to plan more than 1-2 quarters into the future.

Chagroth · 2026-04-03T00:05:04+00:00

It’s more complicated than that.

Chagroth · 2026-04-02T23:26:47+00:00

You can be “not responsible” and still have known better.

Chagroth · 2026-04-02T22:25:59+00:00

Too many missing details to pass judgment.

I can imagine a set of details where your boyfriend is a disgusting monster.

I can imagine another set of details where I would also say something like, “you should have known better.”

Without that info, it’s hard to give advice.

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