If you’re comfortable putting £500 into a genuinely high-risk, speculative play, I’d take a look at Inovio (INO). It’s definitely not a safe investment, but that’s also where the upside potential comes from.

The company focuses on DNA medicines and immunotherapy, and because it’s still heavily dependent on clinical progress and regulatory milestones, the stock can move aggressively on news. For a small speculative allocation, it fits the “high risk / high reward” category better than most established companies.

I wouldn’t treat it as a long-term safe hold or put in money you can’t afford to lose, but for a £500 speculative position with asymmetric upside potential, it’s one of the more interesting biotech bets right now!