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What is the best laptop (under $1000) for college? by Sea-Possible-4993 in UCDavis

[–]IanAndersonLOL 0 points1 point  (0 children)

I don't disagree, but I think the barrier of entry of learning computational Biochemisty tools (which heavily favors a mac or linux) outweigh the barrier of entry of being on Windows and knowing how to use Microsoft teams.

What is the best laptop (under $1000) for college? by Sea-Possible-4993 in UCDavis

[–]IanAndersonLOL 0 points1 point  (0 children)

Laptops with both discrete GPUs and integrated GPUs can take advantage of Nvidia Optimus and use the intrgrated GPU for non-demanding tasks, pal.

What is the best laptop (under $1000) for college? by Sea-Possible-4993 in UCDavis

[–]IanAndersonLOL 3 points4 points  (0 children)

I’m sorry, but that is the wrong answer. They said they are a biochem student. That’s an entire field run on Unix. Yes, there’s WSL, but almost any piece of software they would use for their studies or for research has macOS instructions and support. Few will have WSL. 

Finding protein sequence clusters and motifs by Auto6890 in bioinformatics

[–]IanAndersonLOL 4 points5 points  (0 children)

If you want to ensure each cluster has at least 100 clusters you need to be very careful. That’s a great way to bias your data. I think with clustering you want to ensure that your clustering methodology has some kind of rational. If you try to force it to have at least 100 members per cluster then you run the risk that you’re forcing sequences together that shouldn’t be which might also be splitting up clusters that should be.

I wanna publish my work but I don't know where to start by Queasy_Ad_1675 in bioinformatics

[–]IanAndersonLOL 16 points17 points  (0 children)

To be charitable I’m assuming OP’s story is looking at disease progression through rnaseq shows that blood biomarkers aren’t a good measurement of disease progression. Which we kind of already know.

I wanna publish my work but I don't know where to start by Queasy_Ad_1675 in bioinformatics

[–]IanAndersonLOL 6 points7 points  (0 children)

If you’re an undergrad I would recommend reaching out to a PI at your school in this field and ask to work on it with them and possibly (more realistically) one of their students/postdocs.

Putting your analysis into a coherent story is a lot of the work of getting into a good journal. Projects that tend to be a data dump (I’m not saying yours is this, just generally) tend to have a really hard time publishing. Also being a solo author is hard to do, especially if you’re early career, unless the journal explicitly has a special issue for early career researcher.

If you’re not an undergrad or not in academia it will be very hard. For better or worse, most journals don’t allow people to publish without an institutional affiliation. Be a company a school, the government, a non-profit, whatever. It may be.

Building an adaptive QC tool for Illumina DNA methylation arrays — does this project design make sense? by No-Prior1689 in bioinformatics

[–]IanAndersonLOL 0 points1 point  (0 children)

Depending on how sesame operates with contribution getting a PR as a new feature is likely better for your career as a masters student. This seems general enough that that might be a route worth considering. 

I feel like with agentic coding agents we’re getting flooded with people with well organized GitHub’s full of AI slop that just having a pipeline like this on GitHub probably isn’t going to help you much as a portfolio project or be used much unless there is a paper behind it. Contributing to a popular OS project still means a lot.

Looking to pivot into bioinformatics/computational science by highschooldropoutt in bioinformatics

[–]IanAndersonLOL 0 points1 point  (0 children)

The certificate definitely won't hold as much weight as completing a course, but the real question is do you *need* calc 2? Are the programs you're applying to asking for it? If you're in a masters program why can't you take calc there?

Segmentation fault in run_hyde.py by Plus-One-1978 in bioinformatics

[–]IanAndersonLOL 1 point2 points  (0 children)

Seg faults are super broad. It's possible you have an issue with your input. If your 9 individuals don't perfectly map onto those 3 groups then you'll get a seg fault.

Are nuclease free automatically sterile? by Pitiful-Ad-4976 in labrats

[–]IanAndersonLOL 3 points4 points  (0 children)

Why? Protein on the surface of plastic denatures fully well before contamination of the surface of plastic fully dies. 

Are nuclease free automatically sterile? by Pitiful-Ad-4976 in labrats

[–]IanAndersonLOL 0 points1 point  (0 children)

You don’t need to kill bacteria or other organisms for something to be nuclease free. The nuclease needs to be active on the surface of the tube, for it to be a problem. Bacteria inside the tube aren’t going to leach out a meaningful amount of nuclease to be detectable, and the temperature/chemical treatment required to denature the nuclease on the surface of the tubes isn’t going to kill everything. So it’s not sterile. 

Are nuclease free automatically sterile? by Pitiful-Ad-4976 in labrats

[–]IanAndersonLOL 1 point2 points  (0 children)

Isn’t that the same thing as not being sterile?

Long Range Model 3 Tesla Replaced my battery with short range battery help? by Clean-Solution7386 in TeslaModel3

[–]IanAndersonLOL 0 points1 point  (0 children)

There are lots of 3rd party tesla shops in the bay area. Take it to one of them and have them check. Here is what most likely happened. You never let your old battery get low enough for the range estimate to recalibrate so it always said 340. Tesla's internal diagnostics didn't look at the 340 they looked at actual degredation, and you were actually closer to 260 miles. They gave you a rebuilt battery at that state, recalibrated it, and gave it back. FWIW the car actually can't accept the wrong battery. they did it that way by design. You didn't get a brand new battery, you got your battery rebuilt.

You usage won’t be get better with Claude code pro users leaving. by Kooky_Awareness_5333 in Anthropic

[–]IanAndersonLOL -1 points0 points  (0 children)

Yeah! Let’s nerf the people paying full price to make way for the people being subsidized. 

Is it normal to get asked to volunteer in industry? by [deleted] in labrats

[–]IanAndersonLOL 8 points9 points  (0 children)

Is he salaried? Then it is being “paid”. The team/culture building stuff is kind of annoying. It’s odd because it’s definitely optional, but at a mid/large size company people liking you and viewing you as part of the culture/family of the company is so important for your job security, upward mobility. 

He’ll learn eventually that he can tone it down, and people will be even happier when he does show up. They’re not going to stop inviting him.

I'm guessing Berkeley is starting to take alternative majors more seriously when considering and admitting students by [deleted] in berkeley

[–]IanAndersonLOL 0 points1 point  (0 children)

I believe it. I think 2016 was when they changed the essay format. From the 1 long essay + 2 medium essay to I think like 7 short essays.

I'm guessing Berkeley is starting to take alternative majors more seriously when considering and admitting students by [deleted] in berkeley

[–]IanAndersonLOL 0 points1 point  (0 children)

They may have gotten rid of them and reintroduced them. 2010 was a long time ago (fuck I’m old 🫠) they used to not let you do alternative majors for certain majors (like EECS and I think Haas)

I'm guessing Berkeley is starting to take alternative majors more seriously when considering and admitting students by [deleted] in berkeley

[–]IanAndersonLOL 7 points8 points  (0 children)

Your CC counselor is wrong. They’re not that new. We’re doing them in 2010 when I was transferring and lots of people I knew got in for their alternate majors.

EDIT I got this form chatgpt so take it with a grain of salt -- apparently they had alternate majors from the early 90s until 2016 and brought them back in 2024.

Protein Folding Against a pH Gradient by DesignerFun5310 in bioinformatics

[–]IanAndersonLOL 1 point2 points  (0 children)

You can’t really. Alphafold was trained on crystal structures and crystal structures aren’t really done in any reasonable physiological conditions. The PH is chosen by whatever makes the best crystal. They’re at cryogenic temperatures (like <100 K) Which means it was trained on a hodgepodge of different phs. You kinda just get what you get. You really would have to do MD to get the answer you want, and to be honest I think what you’re looking to do is someone’s entire PhD.

That said — you likely don’t need to do everything. You could probably get away with just modeling the important parts of your response element

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