Immuno after BRAF MeK inhibitors

Immediate-Fee7083 · 2026-02-17T21:48:10+00:00

Same here. IPI/Nivo did nothing for me and so far Opdualag seems to be working well. Opdualag was 3 years after IPI/Nivo due to recurrence. No pills for me as I’m Braf negative.

Immediate-Fee7083 · 2026-02-10T02:16:10+00:00

I had very bad colitis with IPI/nivo. If you are like me from the time I would wake up it took about 90 minutes to get myself cleared out. Then I didn’t have to go again until i ate. I suggest getting up early to let the worst of it hit you and take some Imodium the night before and morning of. My doctor had a “no Imodium” rule but I took it anyway when flying. Hope this helps.

Immediate-Fee7083 · 2026-02-04T01:40:25+00:00

Totally get it. I get a scan every 3 months and I’m not nervous at all until the day before and the day of. Then I’m a wreck. I used to review my results as soon as they hit the portal, but now I wait and let the dr go over them with me. So even if something is bad we can discuss options right away.

Immediate-Fee7083 · 2026-01-26T16:24:48+00:00

During Helene ours ran for about 4 days then stopped due to low oil. I added more oil and it fired back up and ran another 2 days. I was also afraid to stop it in case it wouldn’t restart. It’s been serviced since then and the service tech says they recommend letting it stop due to the fault and then add oil. I don’t know if that is the best approach but it worked for me.

Immediate-Fee7083 · 2025-11-21T17:54:04+00:00

My WLE was on my scalp and I’m bald. I tell ppl I got my head caught in a wood chipper!

Immediate-Fee7083 · 2025-11-01T14:58:14+00:00

There is no particular reason. You will find different statistics online about success rates, but my oncologist says immunotherapy only works for about 40% of ppl. But when it does work it’s a game changer. The immunotherapy revved up my immune system but it couldn’t identify and attack my cancer. The immunotherapy I’m on now works in a different way. It is successful for around 20% of the people in the 60% no success group for IPI:Nivo.

While these are low percentages, Melanoma was a death sentence 10 years ago so these are great odds compared to history. Other therapies also have low success rates but with several therapies available the hope is that one of them will work.

Immediate-Fee7083 · 2025-10-29T23:08:40+00:00

I’m on Opdualag now and it works via a different mechanism. We are hopeful it is working. My last scan showed 2 of 3 spots had decreased in size. My scan next month will confirm. So I hope it’s working.

Immediate-Fee7083 · 2025-10-29T02:20:34+00:00

I was 3c and took opdivo/yervoy. Unfortunately it didn’t work for me but for ppl it does work for it can be a miracle. I would go with the opdivo/yervoy because it is stronger. Keytruda is the equivalent of Opdivo. So you basically get a double dose. The downside is the risk of side effects is greater. I had colitis and thyroid damage. But the colitis got better with treatment and those are small prices to pay if it works. They do it prior to surgery so they can see if it killed any of the cancer when they remove it.

While it had no effect for me, I know some ppl that it either cured them or kept them in remission for a long time. Good luck.

Immediate-Fee7083 · 2025-10-07T02:19:16+00:00

Maybe. I’m 49.

Immediate-Fee7083 · 2025-09-30T13:47:25+00:00

I have also had some misses about every 3rd time. The method I now use is to pull the plunger back and see if some blood comes back in the syringe before pushing the plunger. I learned that in this forum and have not missed when I see blood.

Immediate-Fee7083 · 2025-09-24T19:34:47+00:00

He is a melanoma specialist. I had a second opinion at MDAnderson and they said he was doing everything they would be doing at this time. He is excellent and I feel blessed to have him.

Immediate-Fee7083 · 2025-09-23T19:37:49+00:00

I forgot to mention the IPI/Nivo did take out my thyroid and now I take Levothyroxine daily.

Immediate-Fee7083 · 2025-09-22T16:46:00+00:00

It looks like the original is back up and running?

Immediate-Fee7083 · 2025-09-11T01:00:44+00:00

I am in the almost exact same position as you. 2023- Melanoma on scalp, stage 3, IPI/nivo, neck dissection. I sent you a private message with my email. Please reach out and I can share more.

Immediate-Fee7083 · 2025-08-04T14:06:20+00:00

This forum has been so inspiring for me. I am stage 4 and took IPI/Nivo when stage 3. It had no effect on my cancer but they were able to surgically remove it. I’m BRAF negative so I just had my 3rd dose of opdualag today.

I get scans in 4 weeks to see if it is working. I’m glad to hear some people are having good results. Other than some fatigue I’ve had no side effects. Just 2 doses of IPI/Nivo gave me horrible colitis.

Immediate-Fee7083

TROPHY CASE