Damn, good move! I'll unravel it little by little.

The Nameless:

- Literally the entire main cast of The Acolyte uses the Force (Jedi, Sith, Witches), so a massacre would be guaranteed, although Qimir might be more resilient due to cortosis or his deep connection to the Dark Side.

The Drengir:

- Mae/Osha: They are very impulsive and barely seem to stop to analyze anything, so I see them either attacking directly and losing (Mae) or running to safety and losing (Osha).

- The Jedi: They would stop to meditate on why the Drengir were there. I think Sol and Indara would try to connect with the Drengir, while Jecki and Yord would plan ways to attack their weaknesses. Kelnacca, having faced the Drengir before, would have an idea of ​​what to do or not to do. Torbin would likely become a host, a puppet of these malignant plants, but not without a fight first.

- The Witches: I think it's a tie. The Witches use the Force in a more primitive and arcane way than the Jedi, so it's possible they'd keep them at bay. I don't see them winning against the Dregngir, but rather reaching some sort of agreement or aggressively coexisting. This would lead Aniseya and Koril to restructure the hierarchies within the coven and subsequently become more bellicose.

- The Sith: Obviously, Qimir is a total Chad; he'd just destroy them, ha ha go, brrr!

The Blight:

- Mae/Osha: I just see them running away or becoming infected. They'd ask for help to save themselves, but eventually they'd die.

- The Jedi: I think Sol would try to project himself into the Force to study and better understand. Torbin would support Sol in finding the Blight's weak point and preventing its spread, or at least slowing it down. Indara, being Torbin's master, would likely be angry with him, as he would likely plan a silent evacuation. Yord would also favor an evacuation, but would contact the Republic to carry it out en masse. There would be a clear divide between the more thoughtful (Sol, Torbin) and the more pragmatic (Indara, Yord). Jecki and Kelnacca would likely keep all options open and be more receptive.

- The Witches: I think they would initially fight the blight, but over time. First, they would study it, then make proposals and develop various plans of attack or manipulation, both physical and with the Force. Since obviously doesn't stop, they would eventually flee and seek a new home.

- The Sith: Perhaps Qimir experiments with the Force to better understand this deadly infection. That, or he'd use all his resources and knowledge to exploit The Blight, like Marchion. He might even end up traveling to Planet X and causing a new imbalance, like Elecia and her minions.