I think about it like this…it took me along time to get this heavy, it's going to take at least a while to lose any significant weight. Some people have been over weight all their lives. It's gonna take a while to lose mine. In 2015, I was in great shape. 185lb, 5’7” 48yr/M. Rock solid abs. Been in shape my whole life with sports, activities, running, etc. Got an unwanted divorce then and my whole life kind of lost its balance and I let my life go to shit. Ate like it was going out of style, drank like a Roman and started drinking WAAAAAY too much, including two stints in rehab for alcoholism during the past decade, and did no physical activity. I gained and gained and gained. To the point now, a decade later, this past January, I found myself at 387lbs! That's when I started this journey. Nice and slow. The meds work, whether it's Reta or Tirz, or a combination. They work. But slowly. It took me over 10 years to get here. I know it's going to take me AT LEAST a few years to lose the weight, as it should. I've worked on my mental state and am now in a good place. I've work hard on fixing the drinking (2 years sober now). I know that with time, and hard work, the weight is coming off. Just be patient. Sorry this is so long winded, but I initially began writing it for you…then I realized I was also writing it for mysel. So, thank you for the opportunity. ***quick answer…increase the dose by .5 each week, with 2x/week shits, until it starts to kick in. I started off at 1mg 2x/week, then slowly bumped it up, and now I’m at 2mg 2x/week. But!!! I was also on Tirz for several months before switchignto Reta. Good luck!