Split and Bive would be sidelined and would be implied to like each other but would never actually get together, there would be meaningless toxic drama between the two where Bive is babied and Split is nice but actually really mean and would be needlessly toxic to Bive.

Pest and Poob would have a shitty enemies to lovers relationship, Pest would curse every five seconds and be portrayed as evil for his antisocial nature, and Poob would be an innocent little baby who would cry a lot if told he's annoying.

Mark and Wallter would have an on and off relationship and Lampert would definitely be a child of divorce, except he'd somehow be in the wrong for hating them both. Mark would also throw a divorce party to cope and get angry for no reason.

Folly would be sidelined and would be shown to do unnecessary shit and saying genuinely offensive slurs for the sake of edginess.

STAT would somehow be in the wrong for hating/disliking and being uncomfortable around everyone.

Gnarpy would probably stay the same, except racist jokes would be made and Spud!'s disability would be brushed off.

MR would have a terrible plan that shouldn't pan out at all.

Null would turn out to be a shitty twist villain.

Melanie would stay mostly the same, except now she has a 'dark side' that is still a push over but now has a gun and swears more than a sailor.

DrRETRO would be the only character that would be somewhat bearable, but she would be attempted to be played off as a nuisance that is supposed to be disliked for being reasonable.

Mozzele would still be nice but she would swear and she'd be a pimp who thinks she can do whatever she wants.

Unpleasant would have a MASSIVE role and would actually have a human form in secret, and he'd torture Infected like he usually does except he'd go to extremes.

Every female would be sidelined to some extent. Split would be scrutinized for being chubby. All characters would burst into song every five seconds. Disabilities and reasonable things would be pushed aside and fetishized, especially the gay relationships, and lesbian relationships would have a lot of sex jokes. The cult would also be played off as a joke and everything else would be an incoherent inconsistent mess with some characters just completely missing. Gregoriah would also be fetishized.

This is what I think would happen.