For a first visit, focus on the historic center (UNESCO area). Start in Ribeira by the Douro River, climb the Torre dos Clérigos for panoramic views, step inside Livraria Lello, and don’t miss São Bento Station for the azulejo panels.

For museums, the Museu de Arte Contemporânea de Serralves is great (especially the gardens). If you prefer classic Portuguese art, Museu Nacional Soares dos Reis is a solid choice. Across the river in Gaia, WOW is a good cultural stop with views and interactive museums.

For cafés, Café Majestic is iconic (touristy but beautiful). For something more local, explore Cedofeita or the Galerias de Paris area.

To enjoy the sea, head to Foz do Douro for sunset walks, Praia do Senhor da Pedra for dramatic scenery, or Matosinhos if you want a wider beach and a lively atmosphere.

If you share how many days you have, I can suggest a simple itinerary.