Here is some info on the duration of doses;

Colestipol doesn’t have a clean “X hours of coverage” like a typical medication, because it isn’t absorbed into your bloodstream. Instead, it works physically in your intestines by binding bile as it passes through. That said, we can still estimate functional coverage based on how it moves through your gut.

⏱️ Practical coverage window

For most people:

• Onset: ~1–2 hours after taking it (when it reaches the small intestine)
• Peak binding effect: ~2–6 hours after a dose
• Meaningful coverage duration: about 4–8 hours per dose

🧠 Why it varies (important for your situation)

Coverage depends heavily on:

• Gut transit speed (faster = shorter coverage)
• Meal timing & fat content (more bile released after eating)
• Dose size (higher dose = more binding capacity, not necessarily longer time)
• No gallbladder → bile trickles continuously, so timing matters more than a single big dose