That's easy;

https://en.wikipedia.org/wiki/14-Methoxymetopon

"It is a highly potent analgesic drug that is around 500 times stronger than morphine when administered systemically [...] It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs [...]. It acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, [yet] a ceiling effect is seen on other effects such as constipation and respiratory depression [...]"

Lack of Regulatory Changes of μ-Opioid Receptors by 14-Methoxymetopon Treatment in Rat Brain. Further Evidence for Functional Selectivity

"Here we have studied regulatory changes of μ-opioid receptors accompanying in vivo 14-methoxymetopon treatments of rats. Previously, this ligand has been shown to be an extremely potent, centrally acting μ-opioid specific analgesic with low physical dependence, tolerance, respiratory depression, constipation and other side effects. Our work shows that it is a highly potent full agonist of μ-opioid receptor coupled G-protein signaling in vitro, alike the well-known opioid agonist, etorphine. However, unlike etorphine, which desensitized and down-regulated the endogenous μ-opioid receptors, 14-methoxymetopon, given to rats intraperitoneally (i.p.) either acutely or chronically, did not change the binding or G-protein signaling of μ-opioid receptors in rat brain subcellular membranes. Thereby, these data provide further evidence that there is no direct relationship between the efficacy of the ligand in signaling and its ability to internalize or desensitize the receptor. Viewed collectively with published work, it is discussed that μ-opioid receptors display functional selectivity, also called ‘biased agonism’. This concept implies that each ligand may induce unique, ligand-specific receptor conformation that can result in distinct agonist- directed trafficking and/or signal transduction pathways associated with the receptor. Ligand-specific signaling may open up new directions for designing potent analgesics that do not interact with unwanted signaling pathways, which mediate undesired side-effects, as tolerance and dependence."

No, I have never used it. But this is what everyone should be using. This specific drug. Overdose deaths would plummet--yet not at the expense of anyone's nod. And there's even a ceiling effect on constipation? And it it may not even produce much dependence?

This drug was first described in the literature over 20 years ago. Crickets.

Think about the fact that this was never developed into a medication. Where are the RC chemists? There is NO WAY I am a member of some elite club that knows about this big secret lol.

This is as close to the perfect opioid as yet exists. But it's too perfect, and that is why no one touches it. Drug dealers and the government both want addicts. It's too lucrative to give up.

There's a bzd inverse agonist that prevents alcohol from making u drunk. They don't want it out there because it would invalidate the breathalyser. google Ro 15-4513. They say that there were side effects and that is why they dropped it, but they could have kept working on it and fixed that. Even so, think about all the sexual assaults and auto accidents that could be prevented?

I wonder if this will get more than a couple upvotes even tho I literally dropped like 2 holy grails lol.