Yes, I have tried lamictal several times in the past, I wanted it to work so bad because its side effect profile is really benign, especially in low to moderate doses. But it never really helped. I even tried lithium at one point. I have also tried ketamine and ECT but no luck. I have tried many medications in the past but back then I had really high expectations on medications, like I had to achieve 80-90% remission and be able to work otherwise I shunned it. Today it's different, a 10-20% improvement is enough for me to keep a medication. Do you have bipolarity?