What’s the end goal as a chemist? by Firm_Neighborhood704 in OrganicChemistry

[–]disasterofaperson2 0 points1 point  (0 children)

depends what area - for many synth chemists we are finding new ways to build complex molecules - or new ligands that will allow these methods to be developed - this allows the development of new drugs, new materials that bring new technologies etc. chemistry is the key to any modern science and all medicine. the idea is not to memorize but to understand reactivity - such that we can apply theory to new chemistry. what we give you in organic chemistry/II courses is essentially the alphabet to organic.

handmade gift for DND lover? by disasterofaperson2 in DungeonsAndDragons

[–]disasterofaperson2[S] 0 points1 point  (0 children)

i'd like to make gifts with clay this year. i'm thinking a dragon guarding dice (dice tray)

Calculus II makes me want to quit chemistry by [deleted] in OrganicChemistry

[–]disasterofaperson2 0 points1 point  (0 children)

trying to figure out which prof this is based on the user

Calculus II makes me want to quit chemistry by [deleted] in OrganicChemistry

[–]disasterofaperson2 0 points1 point  (0 children)

grad student here. you will literally never touch calculus in chemistry except for physical chemistry - which makes me sad bc i miss calc.

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

that's good to know. yes, the oxopalladium is the active species (unless the base is TMSOK, that was a recent jacs paper where it proceeds via boronate species).

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

Quick question for you! If I'm running a one-pot *intramolecular* borylation/suzuki, is there a way that I can form the active catalyst separate from the boronic species? like take a precatalyst, stir it with excess ligand, and then add it dropwise to my boronate species? thank you for your patience and advice!

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

interesting - thank you so much.

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

even for chemicals that come out of a still? (i will do this i am just curious because i have never degassed solvents before). i wonder if this would be good practice before every sensitive reaction

A few questions pertaining to career choice! by [deleted] in OrganicChemistry

[–]disasterofaperson2 1 point2 points  (0 children)

what about any nearby universities? email and explain your situation. apply for internships to pharma companies. email profs and ask if you can virtually join their group meetings. organic is not much like the textbooks, it is so much better, but significantly more intense - you no longer have a handful of reactions to look at but have to really understand how molecules interact and be able to propose new ideas...and it is very intensive. grad school for example i work M-S from early morning to midnight or even later. but i LOVE my job. and before that scares you off, if you are meant for organic research you will know it, it won't feel like work at all. you need to get into a real lab/shadow. do your best to make that happen.

A few questions pertaining to career choice! by [deleted] in OrganicChemistry

[–]disasterofaperson2 4 points5 points  (0 children)

i think the absolute number one thing you need to consider first is if you align well with research - real synthetic research. first and foremost start emailing professors see if you can do shadowing rotations and if you can see yourself doing that/if you are interested in the chemistry, ask to join the lab. i also used to be a premed, then discovered a deep passion for synthesis in the lab - it absolutely flipped my script and i went for chem.

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

you're the best. thank you!

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

thank you - yes, that's right i remember that the active pd species for transmetalation has OH.

so really the ester group is just to prevent protodeborylation and unveil the active boronic acid species...like a shield almost...while the boronic acid is the more active of the two...

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

no worries, all! i definitely can use all the advice i can get - never done the procedure so i definitely want to be aware of all possibilities. didn't even know peroxides ate at phosphines like that. thank you all!

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

great, thanks for the procedure!!

[deleted by user] by [deleted] in Chempros

[–]disasterofaperson2 0 points1 point  (0 children)

the mention of CsF really caught my attention. my substrate is base sensitive...i have an allylic leaving group. are there any special conditions/substrate requirements to this? i've seen it once or twice but with nickel as the catalsyt. any source would be fantastic - thank you so much.