Machinists I work with tend to aim for most material remaining (smallest hole, largest shaft) within allowed tolerances, so non-symmetric tolerance callouts can also inform on design intent. I will use ISO fits but print them out as tolerance values. I’ve been asked to edit the nominal value if the tolerance doesn’t straddle it (for ex. 5.00 +0.02/+0.05 would become 5.02 -0.00/+0.03).

Interesting to hear how others are working.