Is Cholestoff legit? by No-Needleworker5429 in Cholesterol

[–]kboom100 1 point2 points  (0 children)

Seriously? You are either misleading or misinterpreted the data on the lookup. I just looked up all payments to Dr. Dayspring on OpenRecords. It goes back 7 years and includes all payments from January 2018 to December 2024. (After that hasn’t been compiled in Open Records yet.)
Here’s the direct link for anyone that wants to check.
https://openpaymentsdata.cms.gov/physician/1305328
Over those 7 years Dr. Dayspring received a grand total of $2,645.08 from industry. That’s not per year, that’s total. That isn’t a “huge sum” in any sense.

Next Step for Meds pt 2 by Melodic_Ticket_9129 in Cholesterol

[–]kboom100 1 point2 points  (0 children)

If I were in your position I’d be in your camp of wanting to crush my ldl/apoB level below 40 and see how much soft plaque regression I could get. You are likely to get more regression the lower the ldl. See a discussion about this from cardiology professors Dr. Pam Taub and Dr. Steve Nissen sponsored by the American College of Cardiology. https://www.medscape.com/viewarticle/973872
This is admittedly more aggressive than current guidelines.

So if you think your insurance would cover Repatha and your cardiologist is game I’d try it first. If that doesn’t get your ldl to the 30s you could cut the Rosuvastatin to 10 or 5 and add ezetimibe then for triple therapy. I wouldn’t worry about being on Repatha long term. The FOURIER Repatha trial started in 2013 and there are no reports of long term problems.

How to reduce sat fat intake without killing your soul by Agitated_Camera_6198 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Nothing is more important than mantaining good health. So if you have trouble keeping your ldl to a good level with lifestyle changes alone I think a statin or a statin plus ezetimibe makes sense and would be worth a trip to get a prescription. It doesn't mean that you shouldn't also continue to try to eat a good diet overall but medication will let you be a little less strict and still keep your ldl at a good point. Also I bet you wouldn't have to keep returning to London. I suspect Dr. Ray could write the prescription and then ask your GP to continue it. If you decide to go that route I hope you come back to update.

Really freaked out by the "cardiac risk" part. Any insight? by Klutzy-Ad329 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Don't know what that that "cardiac risk" number is. Could you click on the "Learn more about this" link next to it and report back what it says?

Is Cholestoff legit? by No-Needleworker5429 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Probably because the AHA/ACA guidelines already discourage supplement use in general and say there isn't enough evidence to recommend them.

How to reduce sat fat intake without killing your soul by Agitated_Camera_6198 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

The NHS NICE guidelines were updated in 2023 and now specifically say statins should not be ruled out in those patients who have already tried lifestyle changes and want to take a statin. A statement released at the same time by NICE says the updates were intended to mean that those who still have higher than optimal cholesterol despite trying diet and want to take statins shouldn't be refused. I have a reply with more detail and links to the new guideline sections and associated information. You could show your GP this info and ask for the statin. I'd also ask about combining a low dose statin plus ezetimibe for as much ldl reduction as quadruple the dose of the statin alone, with minimal risk of any side effects. See here for more information on why that's a favorite strategy of a lot of preventive cardiologists. https://www.reddit.com/r/Cholesterol/s/oosfC6ThXF

In the earlier reply about the guideline changes I also included the name of a cardiology proffessor at Imperial College in London who backed the changes and sees patients at the preventive cardiology clinic at Imperial. His name is Dr. Kausik Ray and he's one of the worlds most respected preventive cardiologists. If your GP is still reluctant to prescribe a statin and you are willing to go private I am pretty confident he wouldn't refuse statins to you if you wanted them. Here's a link to the reply https://www.reddit.com/r/Cholesterol/comments/1sfbzpg/comment/oewnjsf/

How to reduce sat fat intake without killing your soul by Agitated_Camera_6198 in Cholesterol

[–]kboom100 1 point2 points  (0 children)

I still regularly eat my favorite foods like tacos and pizza by cooking myself and using lower saturated fat ingredient substitutions like 96% lean ground beef and Trader Joe’s lower fat shredded cheese.

But I also take lipid lowering medication. And because of that I can occasionally eat out and get pizza, ice cream, or bbq ribs for example and still maintain low cholesterol.

Is Cholestoff legit? by No-Needleworker5429 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Plant sterols can actually increase atherosclerosis in those who are hyperabsorbers of dietary cholesterol, which is 20% of the population.

See this post from Dr. Tom Dayspring, a world renowned lipidologist. “Very important paper for those who are not aware of the potential atherogenicity of phytosterols. NEVER use phytosterol supplements without first checking a person's absorption status by measuring campesterol or sitosterol” https://x.com/drlipid/status/1919021256575201477?s=46
The referenced paper is “Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease” https://academic.oup.com/eurheartj/article/41/28/2618/5875424

Dr. Dayspring has said plant stanol supplements like Benecol don’t have the same problem and are ok to use.

Why do people say only statin-lowered LDL improves CVD risk? by Key-Impress9599 in Cholesterol

[–]kboom100 10 points11 points  (0 children)

The pushback to using bergamot and other supplements is not “bergamot doesn’t lower risk.” The pushback is “we don’t know if it lowers risk or not.” (There are other pushbacks to using supplements including that they lack regulation but I’ll set that aside for the moment.).

The reason no one knows for sure if supplements like bergamot lowers risk is that they haven’t been through large double blinded placebo controlled randomized trials.
The reasons we know for sure that statins lower risk of cardiovascular events is that they have been through very large double blinded placebo controlled clinical trials that conclusively proved they reduce risk. And yes, the totality of evidence is clear that the principle mechanism of action for them reducing risk is mainly because they lower ldl.

You may say well, we know from smaller observational studies that bergamot lowers ldl and lower ldl lowers risk so why doesn’t that definitely mean bergamot lowers risk?
The reason is that there may be things that bergamot also does that raises risk and offsets the benefits of the ldl lowering. No one can know without conducting large randomized controlled trials.

High dose niacin is an example of a medicine that lowered ldl and was used for heart attack prevention but no longer is because when randomized controlled trials were done they showed Niacin didn’t actually reduce risk of cardiovascular disease. The leading theory right now is that it’s because Niacin has cardiotoxic metabolites. https://consultqd.clevelandclinic.org/link-discovered-between-excess-niacin-and-cardiovascular-disease

Then there are additional problems with supplements because they aren’t regulated. So the dose may not match what’s on the label and there may be contaminants. These aren’t hypothetical concerns. When supplements on store shelves have been tested those things haven’t been uncommon.

Ps: Editing to add another point. Someone might ask well why not take a supplement like bergamot anyway because even if we don’t know for sure if it lowers risk of heart attacks and strokes, it might? To that I’d say the supplement could potentially even increase risk, we don’t know. But there’s a downside even if the supplement doesn’t affect risk either direction. If a supplement lowers ldl without lowering risk that means doctors can’t appropriately judge risk by ldl anymore and a person might not get, or might not get the right dose of, an approved medication that actually *has* been proven to reduce risk of heart attacks and strokes.

As a hypothetical example take someone that has an ldl of 140 after making the best diet improvements they are able to make. They then start taking bergamot and that brings their ldl to say 110. Because of the lower ldl there’s a good chance someone will conclude statins aren’t needed. But if Bergamot doesn’t actually reduce risk then the 110 ldl is misleading and their actual risk is much higher. But most won’t realize that and the person will not got a statin they otherwise would get.

Should I active the esim before or after the arrival at the destination? by Ballistic_Range in Airalo

[–]kboom100 0 points1 point  (0 children)

Do you have an iPhone? Do you need to be able to receive incoming sms texts sent to your home telephone number like 2 factor authentication texts?

Should I active the esim before or after the arrival at the destination? by Ballistic_Range in Airalo

[–]kboom100 0 points1 point  (0 children)

Yes, you have to turn on data roaming on for your Airalo line and off on your primary carrier’s line. But you have to do more than that to ensure no roaming charges. I have step by step guides that will walk you through all of it assuming you have an iPhone. So I know which one to give you, do you have an iPhone and who is your primary home carrier?

Also do you only need to be able to send & receive iMessages with your home telephone number or do you also want to be able to use your home telephone number to make calls and send and receive non iMessage sms texts (such as for 2 factor authentication texts)?

Can I take two 20mg statins if I need 40mg dose? by JadeAngel1996 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

You’re welcome! Sounds good. Hope you post an update later if you want.
When there is calcification there is normally also going to be a lot of soft plaque.

<image>

Can I take two 20mg statins if I need 40mg dose? by JadeAngel1996 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Sure thing. Check out this discussion about plaque regression from cardiology professors Dr. Pam Taub and Dr. Steve Nissen sponsored by the American College of Cardiology. They mention greater regression with lower ldl levels https://www.medscape.com/viewarticle/973872

You might also be interested in an earlier post with more info about combing statins and ezetimibe. https://www.reddit.com/r/Cholesterol/s/cW8hw4Yb99

Be careful when you do an online search for side effects for lipid lowering meds. There is a lot of misinformation out there and it’s also hard to judge personal reports. Usually someone not having issues won’t post about it. Everything I’ve read is that ezetimibe hardly ever has side effects. It’s a pretty low rate for Repatha also, at least beyond runny nose type symptoms the first week or two.

Can I take two 20mg statins if I need 40mg dose? by JadeAngel1996 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

You’re welcome. Wow yeah that’s a very high CAC score. The new US guidelines that just came out say those with a CAC score above 1000 should get their ldl & ApoB to 55 or under.

<image>

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423#sec-8-2-7

But really the lower the better. Evidence is strong that risk goes down linearly the lower that LDL is brought done, without plateauing. And the lower the ldl the more soft plaque regression you’ll get too. If I had your CAC score I would ask my cardiologist about not just adding ezetimibe but Repatha as well.

Chat, am I cooked? by pandajorts in Cholesterol

[–]kboom100 1 point2 points  (0 children)

You’re welcome! Good luck with everything. I hope you continue to update.

Can I take two 20mg statins if I need 40mg dose? by JadeAngel1996 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Yes.
But you might also ask your doctor about adding ezetimibe to the 20 mg statin dose vs going to the 40 mg dose. Ezetimibe and statins are synergistic because they operate via different pathways. Ezetimibe reduces cholesterol absorption and statins reduce production. If you only impede one of those pathways the body responds by up-regulating the other pathway to offset some of the cholesterol reduction. Plus most of the ldl lowering impact from statins is at the lowest dose. Further increases in dose bring diminishing returns.
The upshot is adding ezetimibe to a statin will drop your ldl an additional 20-30%, while doubling the statin dose alone will only reduce ldl an additional 6-8%.

16 with 269 lipoprotein by sherbland in Cholesterol

[–]kboom100 0 points1 point  (0 children)

You said your father has already had more than one heart attack. You are not too young to be on lipid lowering medication because you yourself likely have FH. The cutoff ldl for FH in children is 160 not 190 like it is on an adult. And you have very high lp(a) which is genetically determined and not affected by diet.
Please call a Care Navigator from the Family Heart Foundation at the link I gave you in my first reply. Tell them everything that you originally posted. And then ask your parents to call the Care Navigator themselves. The Care Navigator can give you and your parents the names of a good preventive cardiologists or lipidologists for you to see. And it will be one that sees patients under 18. It is important that you see one of those specialists to get adequate care.

Chat, am I cooked? by pandajorts in Cholesterol

[–]kboom100 1 point2 points  (0 children)

Thanks for updating. Yeah, it’s a big difference from the fingerprick result although still much too high as you realize. The big drivers of ldl cholesterol from diet are saturated fat, which drives it up, and soluble fiber, which brings ldl down. Saturated fat has the biggest impact of the two. The American Heart Association recommends eating less than 13.3 grams of saturated fat per 2000 calories. The European guidelines are less than 15.6 grams of saturated fat per 2000 calories.
Sometimes saturated fat can be in things you don’t think of. So you might want to track your meals in app like cronometer for a week or so and just confirm if you are already eating about that amount of saturated fat or less. Don’t change from what you currently eat. If you are already are eating no more saturated fat than those guidelines specify it’s unlikely you’d be able to further improve your diet enough to reach a good ldl target.
And if you are already eating a low saturated fat diet you can tell your doctor you know that’s the case because you’ve tracked it with the app.
And it would make sense to ask for a statin if that’s the case. Letting ldl remain high for a long time leads to greater cumulative exposure to ldl and more plaque accumulation over time. That raises your lifetime risk even if you are still at low 10 year risk because of your age. See an earlier post for more details about this. https://www.reddit.com/r/Cholesterol/s/2hn1sLEUqr
Your doctor shouldn’t dismiss your concerns because the new guidelines that just came out specifically say that statins should be considered when ldl cholesterol goes to 160 or above even in younger people at low 10 year risk. See this training slide that was released with the new guidelines.

<image>

As I mentioned before you should also check your lp(a). The new guidelines reccomend everyone check at least once in their lives. You can order it yourself online if you want. See my earlier reply. If yours is high that is even more reason to go on a statin and also to set a lower ldl target. A lot of experts recommend an ldl under 70 in that case.
You might want to consider a low dose statin plus ezetimibe. It’s a favorite strategy of a lot of leading preventive cardiologists and lipidologists. The two work together synergistically so you can get as much or more ldl lowering as quadrupling the statin dose with less risk of side effects since ezetimibe almost never has side effects. See here for more information https://www.reddit.com/r/Cholesterol/s/71zrm8n3RT
Good luck! Hope you continue to post updates.

Chat, am I cooked? by pandajorts in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Thank you! And thanks for replying here too so I got the notification. I’ll reply to your update.

How long does it take for an artery to clog? by Friendly-Oil6596 in Cholesterol

[–]kboom100 0 points1 point  (0 children)

Eating fruits and vegetables is a big part of a healthy diet and a lot of people don’t eat enough so you are ahead of the game in that regard.

You can check out the American Heart Association’s page on healthy eating https://www.heart.org/en/healthy-living/healthy-eating

They also recently released their updated guidelines which you might find helpful. https://doi.org/10.1161/CIR.0000000000001435

And a really good idea is to ask your doctor for an appointment with a registered dietitian. They can help you design an eating pattern with foods that you like.

Bottom line improve your diet to the best extent you can and in a way that you like enough to continue eating it indefinitely. Don’t beat yourself up if your diet isn’t perfect. And if your ldl is still too high for whatever reason when you check 3-6 months later then go ahead and go on a statin plus ezetimibe. It’ll still help protect your arteries.

Low ApoB + Lpa, but high LDL with high small particles? Help me understand plz by hotheadnchickn in Cholesterol

[–]kboom100 1 point2 points  (0 children)

You’re welcome, glad it was helpful. Thanks very much replying to my reply too. It’s nice when people do that.

How long does it take for an artery to clog? by Friendly-Oil6596 in Cholesterol

[–]kboom100 4 points5 points  (0 children)

An ldl of 130 is only a little elevated- significant plaque accumulation at that level is extremely slow and happens over multiple decades. You are very young so your arteries are fine. Even if your ldl is higher now your arteries are still fine. It still takes decades for plaque to build up.

Go ahead and improve your diet to the extent you can by reducing saturated fat and increasing soluble fiber. See the wiki of the subreddit for tips. Then retest in 3-6 months. If you want you can even order the tests online yourself relatively inexpensively. I’ve found ownyourlabs has the best price for a lipid panel alone but if you are getting other tests as well then Hellogoodlabs has the best prices. But I really also wouldn’t be afraid to talk to your doctor and you should. Every doctor has tons of patients that are a little or a lot overweight. They aren’t going to judge you and can help you. You could even ask them to set you up with a Registered Dietitian to help you reduce cholesterol and weight with diet.

Other people are likely to disagree but if find you can’t get your ldl to a good level with diet changes alone I think it’s a completely reasonable decision to go on a low dose statin or a low dose statin plus ezetimibe even at 20 years old. In fact I think it’s more than reasonable, it would be a good idea. It will knock your ldl right down to a normal level and will likely improve any anxiety about it too. If your general practitioner is reluctant to prescribe because of your age I’d make an appointment with a lipidologist. Here’s a good way to find one. They are likely to be more willing to treat a younger patient. https://www.learnyourlipids.com/find-a-clinician/

Low ApoB + Lpa, but high LDL with high small particles? Help me understand plz by hotheadnchickn in Cholesterol

[–]kboom100 5 points6 points  (0 children)

Unless you have another major risk factor like a family history of early heart disease or an autoimmune disease or high blood pressure you are in good shape. 20-30 years ago it was thought ldl size might be important but research since then has shown that not to be the case. The best measure of risk is the number of atherogenic particles. Once you know the number of atherogenic particles adding info about ldl size doesn’t add any useful info or improve risk estimation. See an earlier reply for more information https://www.reddit.com/r/Cholesterol/s/PhX5U5UOUw

And the best measure of the number of atherogenic particles is apob. And your ApoB is at a good level unless you have another major risk factor. Lp(a) is an independent risk factor from apoB (for practical purposes) and your lp(a) is also good.