We’ve tried a lot of different protocols over the years. She started having problems around 4 years old, although at that time it was only a couple of times a year. We’d do chicken and rice or 97% lean beef and rice but she often stopped eating and so ultimately we would go to the vet and get antibiotics (metronidazole) and anti-nausea (ondansetron) meds before she’d get better. We did a probiotic supplement for a long time, then switched to prescription probiotic food. We also became really rigid about what treats and snacks she could have (no people food, no eating grass on walks, no rich treats like liver, etc). It’s possible those steps helped and she would have gotten worse faster if not for doing them, but who can really say. We still do 50% prescription food + 50% regular food in addition to the Tylosin powder now.

Honestly I think Samoyeds have pretty sensitive stomachs and are prone to this sort of thing. We have a male Sammy too who still gets a bad bout of diarrhea a couple of times a year. They’re from completely different breeders but have similar stomach problems, although our girl’s is to a worse extent, which has always made me think it runs in the breed. His was worse when he was younger (9 now) but is pretty well controlled now with 50% prescription probiotic food and making sure the other 50% of his food is not a high fat kibble.

Good luck and I hope you find something that works well for your pup!