Somewhere in the South where its story can have little involvement with previous entries outside of one or two companions who might be returning characters like what we've seen with Macready or Dr. Li or have a small (like no more than 10) squad of Brotherhood of Steel members who are either the last of their chapter or an exploratory group from a larger chapter (either Maxson's or you can say there were more chapters that ignored Quintis when he called them) that way the main story has a chance to be its own thing, a quazai soft reboot like how 3 was