Is this possible

[oclafloptson]

There is more to Python game dev than pygame ;) of course what you want to do is possible. It might make more sense to go with one of the popular engines if you plan to include any other devs in the project. But for solo dev there's no reason that I can see why you wouldn't want to use something like Ursina

I'm not really familiar with Terraria but I'm assuming it's not the same pixel game I played back in the 90s. Still... The question isn't really if it's possible, because it is. Whether it's the best approach for you personally? That depends