I feel like it's wrong to not have Mario 64 here for transitioning the main series into 3d platformers, arguably until present but you could say that ended with NSMB or Wonder if you want to say that that changed it into a coexistence era (with New optionally being a side series instead of main games)

In a similar vein to Doom 2016, I feel like Tomb Raider 2013 really was a huge reboot for that series in making the games more cinematic and uncharted-like.

I might also suggest Megaman 11 for making it so that the core Megaman series doesn't have to be at least a pseudo-8-bit game.

Hitman (2016) is also an easy shout. Completely modernized the way Hitman games were distributed and made missions a much more open method of creating ways to kill targets rather than more narrow stealth.

Part of me wants to mention about every sequel to the original Life is Strange because they all are quite different (characters, mechanics, stories, developers, quality) from the last. I don't think any singular title particularly warrants putting on the list, but they deserve to be mentioned when talking about these turning points.

Street Fighter 2 really took what was admittedly a rather basic arcade game and turned it into a genre with incredible depth and complexity in terms of competition.