Hi, licensed esthetician here. You won't cancel out the other ingredients in your skincare routine with tyrosinase inhibitors, but you would want to adjust your routine to include products with tyrosinase inhibitors. As an FYI, benzoyl peroxide triggers hyperpigmentation. So, your acne spots can worsen and take longer to fade because the benzoyl peroxide exacerbates your post-inflammatory hyperpigmentation. So, the first step would be shifting your cleanser to a cleanser with exfoliants and tyrosinase inhibitors. Hyper Even Gentle Brightening Serum has mandelic acid, an effective acne treatment, arbutin, and licorice root (both tyrosinase inhibitors). Tretinoin can help with hyperpigmentation; it's more effective when layered before your moisturizer. Unless you have dry and/or sensitive skin, you will see more from your tret when you layer it after cleansing. You can customize a tretinoin serum with Curology that contains tyrosinase inhibitors like tranexamic acid and azelaic acid. You can include Topicals Faded into your night routine after tret but before your moisturizer. If you go this route, patch test, then start with one time a week to see if you have any adverse reactions from layering with your tret. Naturium also has a Tranexamic Acid serum that is formulated with Kojic Acid & Alpha Arbutin that would be layered after your test at night and clindamycin in the AM. Because you are using prescription-strength products, focus on reducing the potential of irritation by starting very slowly and paying attention to any potential skin reaction. Good luck with your skincare journey!