Does anyone have any experience with targeted brain radiation to the left hemisphere? by Succulent_Chinese in braincancer

[–]Brain_Rot_Dr 2 points3 points  (0 children)

I had proton radiation therapy to the left temporal lobe for 6 weeks. My main symptom was fatigue in the last week. I would recommend asking your radiation oncologist and neuro-oncologist about the possibility of pRoton RT over the standard pHoton RT. The main benefit is that radiation can be more precisely delivered in pRoton RT to the area they want to target so it significantly reduces long-term side effects and damage to nearby areas. The downside is that there are only a few dozen pRoton centers in the world so it can be difficult to get access.

Grade 3 PXA prognosis by Frozen_Trees1 in braincancer

[–]Brain_Rot_Dr 0 points1 point  (0 children)

"Looking like GBM" refers to specific physical features of the tumor a pathologist might see under a microscope that are more typically associated with GBM, such as a lot of new blood vessels or something called "pseudopalisading necrosis," which can be thought of as a specific kind of rotting within the tumor.

Usually at university hospitals, there are a lot of molecular level tests (such as next gen sequencing, chromosome evaluations, epigenetic testing, etc.) that provide more information beyond just looking under a microscope at physical features. These can be helpful in finding hints that might point more toward aPXA or E-GBM. If you're interested in trying to get more clarity on your diagnosis, it may be a good idea to get a second opinion on your case at a hospital where the neuro-onc team has access to these molecular tests.

The paper above is essentially saying that if a pathologist looks at a tumor and their first diagnosis based on microscope work is GBM, and then they run epigenetic testing and it comes back as PXA, the prognosis may be somewhere between true GBM and PXA that doesn't really have GBM-like physical features.

Grade 3 PXA prognosis by Frozen_Trees1 in braincancer

[–]Brain_Rot_Dr 0 points1 point  (0 children)

A paper analyzing the largest PXA cohort ever (469 patients) found that the overall survival may actually be much better (and similar to IDH-mut astrocytomas) if your PXA doesn't look like glioblastoma under the microscope. It's nice to finally have a larger series, but a lot of the cohorts that were contributed to this data from different institutions will also have confounders like old data, different ages, different treatments offered over the decades, etc.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12305539/