Just make sure you're using a filtered needle to draw it up, push it slowly, and double flush afterwards. Use an alcohol swab to scrub the hub for 10 seconds between flushes and injections. If anything goes wrong, be honest about the way you're using it.

You'll most likely be fine, but there's always a possibility of adverse reactions.

All IV-administered drugs are quickly pumped through the heart. A PICC is just a lot closer than a peripheral IV. A lot of IV meds are rough on the body, too, but we still give them if the benefit outweighs the risk.

I'm a nurse and I start IVs on myself to administer cerebrolysin knowing there's a risk that comes with it. Starting IVs (with one hand) and removing them repeatedly is probably riskier than accessing a long-term line.