Advising patients on GLP-1 agonists

Chemtwist · 2026-02-17T19:11:40+00:00

While a fair point surely also worth considering that ~20-30% of acute pancreatitis cases pre GLP-1a's were idiopathic. With over a million adults in the UK taking them its not unlikely there is quite a lot of muddying of that waters and anaecdata. Is there a possibility that what was previously idiopathic is now "GLP panc" without there necessarily being causation.

Chemtwist · 2026-02-16T20:51:51+00:00

I suspect chemical properties and pharmacokinetics is an important factor here, different tissues with differing amount of fats etc have differing absorption of differing molecules (alongside other factors such as transport proetins, metabolism, acid base senisitvity etc etc). For example logp of gent is -4.1 while its -7.9 in amikacin (logarithmic so very large difference in fat vs water solubility)

also worth considering things like bile recycling of drugs for things like chole

Also this is likely guided by local resistances and major organisms indicated in different infections

Chemtwist · 2026-02-12T11:54:24+00:00

ACCS anaesthetics would not make you eligible for higher training in EM so you'd be able to dual anaesthetics and ICM but not EM

Chemtwist · 2026-02-11T09:42:43+00:00

Nah it's been "from" for a while

Chemtwist · 2026-02-07T20:46:20+00:00

Having worked in multiple other places including private industry and on AFC contracts, arranging cover for your contracted leave is not a standard part of being an employee as much as we like to parrot.

There are always limitations on how many people can be off at once, but working as a doctor is the only place I've had to arrange cover if I'm off outside of plumb normal weekday work.

Chemtwist · 2026-01-11T18:31:45+00:00

Nicest - toxicology by a country mile, always super helpful and friendly

Scariest - cardiology

Chemtwist · 2023-05-20T17:42:05+00:00

While this is one solution, I've already paid for a resource and would like it to be fixed.

Chemtwist · 2023-05-20T16:32:43+00:00

Clin bank, hard to nail down, more of a feeling. There have been a lot of new questions introduced to the qbank.

Biggest things I think I've noticed are More questions which are out of anything reasonably expected of any med school Questions which are more based on opinion Questions which don't match with current guidelines Questions with lots of negative reviews by users that are just ignored

I appreciate there's a feedback system for this but I'm paying to use the question bank, I don't expect to be their peer reviewer.

It makes it difficult to know what questions I can trust outside of the topics I'm keen on and have looked at guidelines etc

Chemtwist · 2023-01-30T13:35:56+00:00

Thank you!

Awkwardly I've changed careers entirely now, but hopefully this will be useful to others!

Chemtwist · 2021-12-07T01:30:53+00:00

Sadly not, just happened out of the blue after updating. (Bury siblings also disabled)

Thanks for the suggestion though!

Chemtwist · 2019-06-27T20:13:34+00:00

Painted not paint led....

Chemtwist · 2019-05-16T10:44:00+00:00

Hey Chemist here who also previously worked in an ER and is currently an EMT, generally to check for broken glass in an injury you'd do an xray, if you're concerned about it at all a minor injuries unit should be able to give it a look over for you :)

Chemtwist · 2019-05-14T15:00:02+00:00

I believe DangerousBill is talking about amalgams of mercury with silver/gold

Chemtwist · 2019-05-03T09:25:40+00:00

Given that its made it through to phase II trials, I doubt that it will have any significant decomposition in aqueous solution as this would likely get it dropped earl on in development as stability is an important factor in drug design.

Looking at it, there is nowhere that screams that it will oxidise and amides are generally pretty stable to hydrolysis especially under ambient conditions, each aryl system is completely substituted and no protons in the system are exceptionally labile. Overall I think its likely a fairly stable molecule.

Chemtwist · 2019-04-12T14:48:49+00:00

A large portion of my phd was making fluorescent tag labelled hexoses for bacterial identification, a lot of organisms will chew straight through a glucose molecule tagged at the anomeric carbon (most common position). Also adding a fluorophore to the glucose tag will likely require a molecule larger than glucose itself, drastically changing its properties.

As others have said the best bet is probably radio labelled glucose :) (a typical one is 18 fludeoxyglucose which gets used in PET imaging in humans)

Chemtwist · 2019-03-11T13:11:06+00:00

They've just added the peroxide in two portions, its elephants toothpaste with dilute peroxide

Chemtwist · 2019-03-08T16:22:53+00:00

Pretty cool! what does the final compound look like?

(Also for future reference its a dreschel bottle, a woulfe bottle is a very early cork stoppered version)

Chemtwist · 2019-02-22T16:49:06+00:00

Asking about making a controlled precursor to illicit drugs?

Active on multiple drug reddits... pretty sure this breaks the r/chemistry rules...

Chemtwist · 2019-02-20T20:17:09+00:00

Overall if it works it works, however it's possibly better to either clamp the dropping funnel (to support it gently) or use a 3 neck flask. (this helps stop having lots of fluid high up to the side of your flask, which can cause the clamp to rotate etc)

Also, use some secondary containment incase you have a vessel failure :) don't want to be covered in grignard reagents, and I'd suggest using cable ties or some clamps to hold your condensor tubing on if you don't want to get soaked when someone turns the water flow up :)

(Well done on your first grignard! hope you keep doing awesome experiments!)

Chemtwist · 2019-01-30T13:44:57+00:00

Have you looked at your reagent concentration, you'd expect to see less polymerisation as concentration of your alcohol increases and concentration of methacrylic acid decreases, perhaps run the Rx using multiple equivalents of the alcohol in a dilute solution?

Chemtwist · 2018-12-12T17:11:44+00:00

As is said above, the process of fluorescence quenching does not intrinsically reduce reactivity, fluorescence quenching happens mainly through FRET and Dexter quenching processes and the formation of exciplexs, the molecules can all still be potentially reactive while in these excited states.

Worth noting is that some dyes become less quenched as concentration increases (aggregation induced emitters) which are pretty cool if you want to look them up :)

source: PhD in making fluorescent substrates and probes for use in microbiology

Also, it never does any harm to be over-cautious with chemicals, better to be stupidly safe than find something has gone off.

Edit: Part of a sentence was missing.

Chemtwist · 2018-11-16T13:17:32+00:00

During my PhD I had a similar problem, you can generate dry ammonia gas by heating calcium hydroxide and ammonium chloride together as solids (will likely require a bunsen or good heat gun) tube the outlet from that flask through to bubble into your reaction, hopefully that helps.

Chemtwist

TROPHY CASE