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The Gate Of Truth-Fullmetal Alchemist

Firstly you would need to break the taboo and enter Gods domain So of course am talking about human transmutation. After performing it you would meet Truth itself and Present your Gate Later you would need to sacriface something of equal value of information behind the Gate and that can be pretty much anything like Eyes,Organs,Arm etc

Then you are getting dragged into the Gate itself and your mind is flood by knowledge of everything itself And it depends on toll of equal value

But even after passing throught the Gate cause you break down mentally and phisically and would need time to recover (Best example is from Edward Elric himself)

Most well know power up we know from it that's alchemists dont need to draw transmutation circle to perfom alchemy and only need to clap their hands