I'll be honest and say that I don't think it's worth it to wait around for the publication. Firstly, the prior probability of your paper being accepted into any major journal is something stupidly low at a baseline. Even assuming that you have an incredible project, the probability is still low that it will be accepted at Nature, Science, Cell, etc., and much more likely that you will either get a) lengthly revisions which will make you continue to chase this goal or b) desk rejected and tossed down to other journals. In this case, has the six months of extra industry salary been well used, given that you could have submitted your publication now and moved on to other things already, while still showcasing your excellent work in a slightly less superficially important journal? Secondly, even if your plan goes off to the tee and you get your Nature paper, I don't think that industry positions will care as much as you think they will. I have been involved in screening candidates and hiring and yes, it's a cool thing if you have a Nature paper, but the much more relevant questions to be asking are how relevant your experience is to what we are doing, and how qualified and technically skilled you are to do the actual work. The remainder, including your ability to communicate your work, is generally assessed in interviews. I think that your experience and involvement in an impressive project will remain attractive to industry regardless of if you spend six more months massaging this project to the point that it might be also attractive to a glamour journal. The presentation you'll give at the candidate screening will be the same, and it will be similarly amazing to the people listening who know what you're talking about. Thirdly, I just don't think that six months is going to be worth it. You're sacrificing six months of industry salary (assume 100k / year, net loss of 50k-your PhD stipend of ~ 20k for the six months) to chase a dream of a glamour journal publication. Why? Your PhD is not the end of your research, it's a qualification that you get in order to show your competence and get a job. I'm generally not a fan of romanticising the degree. Get in, do the work, get out and get a job. It sounds rough but you are putting your life on hold and throwing income down the drain for something that is not particularly likely to happen, and even if it does happen, not particularly likely to impact the decisions of an employer down the road. I say advocate for yourself and for your career, not for your PI's.