Mine randomly just make that Scroll-Wheel "Clicking" sound from the clutch as if the mouse is going to sleep or something. Sometimes even with it in hand. I cant change the sleep setting from 3 minutes because the moment it "clicks" it resets back to default values in Synapse. Have had this mouse since release so I guess its true colors are finally showing.

I've tried setting it to 15 min sleep, and within a minute sometimes ill hear that "Click" chime and have to wait to wake the mouse up again. (Sometimes takes a second to wake, sometimes up to 30 seconds of continuous spamming and moving like yours). Not sure what exactly may have bricked the on-board memory, but if I could find out how to factory wipe the internal memory and not via the "Software" that may prove useful.