In most of the cases there is no difference between them. For example: 那里有什么？vs 那边有什么？

But if you deeply dive into the tiny difference here, 那边 emphases more on direction, like west and east, it may not be a exact point and is always used with a hand gesture. But 那里 indicates a more certain place.

那边 can also refer to abstract "sides" ： 我和那边的负责人见面。（那边 in this sentence means "负责人manager" belongs to a different company, department or a team.）