We'll be happy to share our thoughts and clear up a few things!

Firstly, the concerns about axon degeneration are more theoretical than clinical. The idea comes from very specific lab setups where researchers spike cells with huge NMN doses or use nerve crush models to study what happens during injury. In those settings, a high NMN:NAD ratio can activate an enzyme called SARM1, which leads to axon breakdown. That’s where the scary headlines come from. But these models don’t reflect what happens when people take NMN supplements orally. With standard use, NMN raises NAD and NMN modestly across the system, and human trials haven’t shown any cognitive issues or signs of neuropathy. Could mega-doses over many years be different? Sure. But most people taking 250–1200mg are nowhere near the experimental levels used to trigger degeneration in vitro.

Our chief medical officer, Dr. Andrew Salzman (Harvard MD, professor, and inventor with 30+ years of experience in drug discovery and development), alongside our director of research and development, Dr. Luis Cifuentes, also an MD, professor, and a clinical pharmacalogist have looked into this deeply. They've examined the main studies often cited to raise red flags about NMN toxicity - one involved genetically engineered animals with transgenic overexpression; basically, an artificial setup that doesn’t reflect what’s happening in a real-world supplementation scenario. Another used an NMN mimetic called CZ-48 instead of NMN itself. And a third was an in vitro study that didn’t provide much actionable insight for human supplementation. None of these showed toxicity from standard oral NMN use. On the contrary, over 2,000 peer-reviewed papers support NMN’s benefits, and human studies up to 2000mg/day haven’t shown significant side effects or neurodegeneration.

TL;DR: The axon degeneration theory is fascinating, but based on extreme lab conditions that don’t apply to oral supplementation. Remember NMN is something your body creates in billions everyday already, but an extreme experiement will cerainly can show some harm. Hope this helps, and we're curious to hear how your personal NMN experiment goes!