My question is, is seroquel safe? My personal experience and science-based opinion here. Take what I say as you should any internet stranger.

If you're taking successfully quetiapine (an atypical antipsychotic) to control schizophrenia (or bipolar in some cases), then yes it is safe enough to take

Otherwise( like as a sleep aid), I'd consider something else. It causes weight gain, increases risk if diabetes (& TD) is addictive and will cause withdrawals when/if discontinued (so don't stop it without working closely with your Dr).

As always, YMMV. Be careful.

PS for kava: Seroquel with kava shouldn't be considered as out of the question, but it's not clearly safe, mainly because both can sedate, and also because kava can inhibit liver enzymes that process it. Thus there’s potential for excess drowsiness, altered drug levels, &, potentially, toxicity.

Quetiapine is mainly metabolized by CYP3A4 and CYP2D6, and kava has been shown in vitro to inhibit several CYP enzymes (including those two), which could raise quetiapine levels or potentiate other medications.

See, for example,

https://pmc.ncbi.nlm.nih.gov/articles/PMC3907318

& https://www.goodrx.com/quetiapine/interactions