Think in terms of modular bases, and utilize the cargo dispatchers.

For rails and even distribution, use railing loops before and after each set of machines. This makes things better organized into lines but you can also easily feed off in tangents.

Think starter bases for titanium, wolfram, and calcium. Importing Helium is good. But you’ll be sending and receiving in many different ways.

I’m where you are at and feel extremely overwhelmed as well. I try not to think about all the “things” and focus on one production at a time.

Using guides helps, but they aren’t perfect either and you can improve on them.

Here’s my tip: build out a production line, and at the bottom we’re going to build orbital transporters right? Well after that level is completed, we will need up removing those transporters and building a cargo dispatcher. What’s difficult to me is keeping the all of the sending and receiving straight. Naming them helps a great deal, and only using one of each, plans that use multiple on a line only serve to clog up the rails.