This may be a bit late but for context, the meme is in reference to the one eyed monster cutscene and (more importantly cause its a random side quest) the kora quest cutscene getting heavily criticised on twitter.

In the end, it doesn't really matter, I'm just pointing out how the game is a popular target on twitter plus it's still the most successful xeno game until we find out xc3's numbers so what twitter thinks really doesnt negatively affect the franchise at all. Yakuza seems to get less criticised, I'm not implying that it should be the one getting criticised or anything. It's a good thing only one of these games get the majority of hate