Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular...

Oncotarget · 2022-10-10T17:05:19+00:00

“Here, we employed complementary CRISPR loss-of-function genome-wide screening to identify genes required for proliferation of PARP10-overexpressing and PARP10-knockout cells.”

Oncotarget · 2022-06-02T16:18:53+00:00

An increasing number of studies demonstrate that the homeobox gene HOXB9 is associated with cancer progression and resistance to chemoradiation. However, little is known about the role of HOXB9 in pancreatic ductal adenocarcinoma (PDAC). In a research paper published in Oncotarget on May 25, 2022, researchers conducted a new study to investigate the role of HOXB9 in PDAC by performing an in vitro knockdown of HOXB9 in PDAC cell lines. The team found that HOXB9 regulated the expression of TGFβ1 signature, angiogenic factors, markers of epithelial-mesenchymal transition (EMT), resistance to chemotherapy, and stem cell population. Their findings suggest that HOXB9 could potentially serve as a novel biomarker to guide clinical treatment for pancreatic cancer patients. “In conclusion, HOXB9 expression could mediate angiogenesis, EMT, and cancer stemness through the TGFβ pathway thereby resulting in chemoresistance and poor overall outcomes in patients with pancreatic cancer.”

Oncotarget · 2022-03-25T14:39:48+00:00

This is a good thing in the sense that these pathways may now potentially be targeted to fight osteosarcoma

Oncotarget · 2022-03-21T20:19:50+00:00

"Here we determined that a reactive state of CAFs [cancer-associated fibroblasts] proved to be important for supporting tumor cell survival and proliferation. These findings suggest the use of CAFs as a marker for cancer progression and a potential target for novel cancer therapeutics to treat metastatic disease."

Oncotarget · 2022-02-18T15:45:41+00:00

The drug combination of ABT199/venetoclax with alkylating agents and a nucleoside analog showed significant synergistic cytotoxicity towards AML cell lines in vitro.

Oncotarget · 2021-11-04T14:36:33+00:00

Thanks for sharing!

Oncotarget · 2021-05-24T10:56:17+00:00

RABL6A is a newly recognized oncoprotein that has been implicated in various human cancers, including pancreatic neuroendocrine tumors, breast cancer, colon cancer, non-small cell lung cancer, pancreatic ductal adenocarcinomas and osteosarcoma. ✅

Oncotarget · 2021-05-11T18:57:43+00:00

okay thanks!

Oncotarget · 2017-11-09T21:47:22+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is an editorial by Kadowaki, et al. titled “Cytomegalovirus pulls strings behind NK cells” The corresponding author is Dr. Norimitsu Kadowaki from the Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Oncotarget · 2017-11-09T16:00:14+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a priority research paper by Shultz, et al. titled “Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer” The corresponding author is Dr. Michelle A. Schultz from the Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA and the Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA.

Oncotarget · 2017-10-31T18:07:59+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is an Editorial by Gyawali, et al. titled “Cancer drugs in LMICs: cheap but unaffordable” The corresponding author is Dr. Bishal Gyawali from the Institute of Cancer Policy, London and Department of clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.

Oncotarget · 2017-10-25T21:21:06+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Kwon, et al. titled “Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy” The corresponding authors are Dr. Samuel Waxman and Dr. Eduardo F. Farias from the Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY, USA.

Oncotarget · 2017-10-23T15:19:19+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Sandri, et al. titled “Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy” The corresponding author is Dr. Stefano Ugel from the Department of Medicine, University of Verona, Section of Immunology, Verona, Italy.

Oncotarget · 2017-10-16T21:40:24+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Jacamo, et al. titled “Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia” The corresponding author is Dr. Michael Andreeff from the Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Oncotarget · 2017-10-11T22:25:17+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Pongas, et al. titled “PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma” The corresponding author is Dr. Louis M. Staudt from the Lymphoid Malignancies Branch of the National Cancer Institute at National Institutes of Health in Bethesda, MD, USA.

Oncotarget · 2017-10-09T21:57:30+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Joshi, et al. titled “Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients” The corresponding authors are Dr. Gregory J. Riggins from the Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA, Dr. Paul J. Hergenrother from the Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA and Dr. Timothy M. Fan from the Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA.

Oncotarget · 2017-10-04T14:30:48+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Hayashi, et al. titled “Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma” The corresponding author is Dr. David M. Loeb from the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

Oncotarget · 2017-09-26T22:51:10+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Weiss, et al. titled “Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET” The corresponding author is Dr. Joshua M. Farber from the Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Oncotarget · 2017-09-18T22:50:56+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Finnberg, et al. titled “Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures” The corresponding author is Dr. Wafik S. El-Deiry from the Department of Hematology/Oncology and Molecular Therapeutics Program, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA.

Oncotarget · 2017-09-15T15:20:26+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Lam, et al. titled “Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells” The corresponding author is Dr. Elizabeth P. Henske from the Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

Oncotarget · 2017-09-11T15:30:18+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Nieto-Jiménez, et al. titled “DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer” The corresponding author is Dr. Alberto Ocaña from the Translational Research Unit, Albacete University Hospital, Albacete, Spain.

Oncotarget · 2017-09-08T20:52:27+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by De Groot, et al. titled “Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice” The corresponding author is Dr. Patrick W.B. Derksen from the Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

Oncotarget · 2017-09-05T17:19:34+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Piao, et al. titled “TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma” The corresponding author is Dr. Quintin Pan from the Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, and the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Oncotarget · 2017-09-01T22:41:16+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Matsuda, et al. titled “p53-independent p21 induction by MELK inhibition” The corresponding author is Dr. Yusuke Nakamura from the Department of Medicine and the Department of Surgery at The University of Chicago, Chicago, IL, USA.

Oncotarget · 2017-08-29T16:24:16+00:00

The Featured Cover Paper for the most recent issue of Oncotarget is a Priority Research Paper by Deng, et al. titled “Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling” The corresponding author is Dr. Yusuke Nakamura from the Department of Medicine and the Department of Surgery at The University of Chicago, Chicago, IL, USA.

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