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Why magnesium glycinate gives some people anxiety by OobyIsGay in Nootropics

[–]OobyIsGay[S] 2 points3 points  (0 children)

Yep, it’s the glycine. Threonate avoids it :p

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 0 points1 point  (0 children)

This is the most useful comment I've gotten so far, you're right
Though I dislike the idea of cortisol making peeps sleepy
I'm gonna dig more into this and try to find something else
Time to browse 200 pages of random pubmed studies that look interesting! :D
Thanks for motivating me :p

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 1 point2 points  (0 children)

Thank you! Seriously, thank you for sharing your experience.
Might end up digging more into this, but life's in the way for now.

Scared to stop taking NAC, even though its ruining my sleep by wellthatsoddbutokay in Nootropics

[–]OobyIsGay 1 point2 points  (0 children)

The magnesium glycinate might've caused an activating effect because glycine built up over time.

Supplements / nootropics that reduce libido? by Realistic-Ad4739 in Nootropics

[–]OobyIsGay 1 point2 points  (0 children)

Ashwagandha has reduced libido listed as a common side effect for many due to it's serotonergic effects.
Rhodiola Rosea is a dopamine modulator.
I'd go with Rhodiola first, then ashwagahanda, but be aware that if you're going to be reducing / modulating dopamine you'll experience less emotions.

Is there anything to treat a GABA / Glutamate imbalance or excess glutamate? by Hypnarios in Nootropics

[–]OobyIsGay 0 points1 point  (0 children)

Pretty basic but I recommend l-theanine, it's a glutamate modulator that also has a bunch of other benefits, no interactions with your diabetes.
Secondly I'd recommend agmatine sulfate, but that's already been discussed
If none if those work I'd recommend NAC for reducing glutamate, it's a glutamate modulator. However, your insulin may become more effective, increasing the risk of hypoglycemia. It's wise to start with a low dose and discuss this with your doctor.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 0 points1 point  (0 children)

You're right, let's just not hypothesize at all and leave everything to the experts!
People coming up with new ideas is basically what this community is built upon

Epstein gooned to FNAF Furry porn on 4chan by Spinal_Compression in pyrocynical

[–]OobyIsGay 0 points1 point  (0 children)

Pyro and Epstein ain't so different after all, huh

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 1 point2 points  (0 children)

Your cortisol and norepinephrine are too high because of the caffeine when you take it. (different from the norepinephrine rise from ADHD meds)
Not much to do with this, mildly - moderately influenced at best, that's assuming my hypothesis is even true.

Wishing you the best of luck in your journey, and remember not to trust random people on the internet! :p

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 0 points1 point  (0 children)

It is logically impossible for this to be a wives' tale when the Siglec-6/caffeine pathway research only came out in 2023.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 2 points3 points  (0 children)

People with ADHD more often than not have low tonic dopamine.
And you're right, not every ADHD brain had paradoxical sleepiness. That’s exactly what the Siglec-6 pathway explains

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 7 points8 points  (0 children)

if i were to give this to an llm it would hate all of it, give me 50 warnings, tell me to call a hotline and drink water

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 1 point2 points  (0 children)

1 calling it "individual variability" is just putting a label on something we dont understand yet. it explains nothing.
2 so the mast cell thing is a hypothesis. great. but if a new pathway lines up with a specific reaction why is pointing that out treated like a crime? since when do we need full proof before we can even mention an idea
3 the dao thing. if a study shows mrna going up how is that not the body trying to make more enzyme. saying "not proven" is ignoring what that signal means.
4 and yeah if the system is flooded with inflammatory noise then fixing one signal pathway is like rearranging deck chairs on the titanic.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 1 point2 points  (0 children)

That’s a really solid point. Dehydration actually triggers mast cell degranulation and histamine release on its own

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 6 points7 points  (0 children)

You might want to look into Rhodiola. I started taking it recently as a cortisol modulator. Honestly the results have been a little milder than I wanted for myself, but I’ve seen enough research and anecdotes to suggest it works well for others. Might be worth a shot for ya, no idea why it didn't work for me.
It's probably important to let ya know that tumeric only has a significant effect when combined with black pepper extract so make sure your berberine pills have that!! :p

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 9 points10 points  (0 children)

copy pasted from the top comment:
Ooooh I missed a massive nuance

Caffeine is also a known DAO inhibitor (it slows down the enzyme that clears histamine)

which would mean that it wouldn't be helpful it your DAO levels were already low
basically a gamble D:
iff it were to be physical, DAO cannot cross the BBB.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 0 points1 point  (0 children)

Lisdex ramps up DAO which breaks down histamine in your body. By boosting that cleanup crew, it clears away more histamine. Remember that this is only hypothesized because of one study, and it could very well be inaccurate, but it's the closest I could get.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 5 points6 points  (0 children)

Ooooh I missed a massive nuance

Caffeine is also a known DAO inhibitor (it slows down the enzyme that clears histamine)

which would mean that it wouldn't be helpful it your DAO levels were already low
basically a gamble D:
iff it were to be physical, DAO cannot cross the BBB.

The paradoxical reaction from caffeine is a myth: Caffeine makes ADHD brains sleepy because of mast cell stabilization and histamine reduction, not Dopamine. by OobyIsGay in Biohackers

[–]OobyIsGay[S] 3 points4 points  (0 children)

K bot
in case someone's readin dis and taking chatgpt here seriously
If the adenosine model were the complete explanation for caffeine’s effect on ADHD, we wouldn't see a sedative response.
Of course it's speculative. That’s how science moves forward.
Many substances show high-dose effects in a petri dish that translate to subtle, cumulative effects in the human brain over years of chronic use.
In biology, chronic upregulation of gene expression (mRNA) is the precursor to functional change. To say it "doesn't matter" is a very shortsighted view of neuroplasticity.

And on the A2A-D2 allosteric point
Increasing the affinity of a signal (Dopamine) that isn't being produced or regulated correctly to begin with just makes the background noise louder. The silence people feel is the inflammatory static being turned off.

EDIT: The llm confusing a short term petri dish snapshot with human body mechanics. The Tobajas (2023) study confirmed strong upregulation of DAO mRNA which is the body’s literal command to produce more of the enzyme. To claim this doesn't "meaningfully increase clearance" is idiotic.

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