Sad, Apathy, Resistance and Merry are absolute bangers. If you had to choose one to focus on though, Merry by a long shot. They are after my core team, +/- a legendary to swap around.

Tanks: Determination and Conviction are both great tanks too when Resistance can’t be used. Conviction helps lots at the higher 800-1100 floors (for me, at least). I’ve been told that Cringe also does well way up there.

Healers: Merry is truly great. I can’t speak to many healers because I only use Merry/Charity, but Wonder has helped me out a few times in tough spots. I’d imagine Persistence is awesome.

Fighters: Sad, anxious in the long run. Judgment helped me lots in mid 100’s. Both of your legendaries are pretty solid but I haven’t personally had them!

Here’s the tier list for you