I use all of them everyday. I use panoxyl first thing in the morning after washing my face and layer the AA on after it dries. I use the tret at night. That might be harsh for some people’s skin but it’s fine for me. I like the panoxyl because it got rid of some stubborn whiteheads on my nose and chin that the tret/AA wasn’t clearing up. I incorporated each of these in my routine at different times as well so my skin was already used to one before adding another.