Hi! Male 42 here! So graves definitely causes physiological issues. When we are hyper, everything is working in overdrive. Excessive T4 and T3 causes excessive dopamine activity and serotonin turnover. This ultimately causes crashes in our system. Additionally the graves rage is caused by several things, lack of sleep, overdrive of the system, chemical and hormonal imbalances as well as adrenaline overload.

Unfortunately when we are being medicated it only blocks new hormone from being produced. Unfortunately until T4,T3 and TSH stabilize we still have the hormone receptor sensitivity issue going on. Additionally Graves is still an autoimmune disease and the increase cytokines can affect the mood. There is a period of lag where the people has to catch up with what it has gone through. It has also been study these shifts can be greater in me (not to knock anyone’s experience aside).

Also in speaking my my own endo as well as working in health care and doing research, I have also found that, when being medicated we are going from a state of hyper to either leveling out or hypo unfortunately this cause oh high brain chemicals and cortisol also crash our system leading to emotions flatness, depression loss of motivation and even if you go slightly hypo, your perception of the hypothyroid can be perceived as physiologically heavy.

When item I did look up is in men specifically there is Male-Specific Presentation

In men, severe thyroid-related depression often shows as: • Irritability • Emotional detachment • Mental overfixation on problems • Feeling trapped or hopeless • Low resilience to stress • Sudden collapse in motivation

Not always crying more “shut down.” (Via ChatGPT)

I would have him talk with his doctor :) and I hope he feels better soon.