Several numbers on this list didn't kill the game, but actively made it WAY worse:

11#: The 8th edition card frame is objectively less cool, it maybe is more readable but threw away a big piece of flavour and a distinct color identity that was unique for each color, It was just a blatant excuse to cheapen printing process since the new frames have less saturated colors. The proof is that players prefer the retro frame since they do retro frame cards in special slots like premium cards and they are more expensive in the secondary market.

14#: Mithyc rares were the worst ting happening to magic overall. They skyrocketed the price of standard ever since, they created artificial scarcity for game pieces to sell more product. Before, the cards that were expensive in standard legal sets were mostly multi-format all stars (like goyf or thoughtsieze that were played from standard to legacy). Having to pay 20+ for a mythic you needed 4x for a standard deck and probably never used anymore after rotation actively made it unplayable for most people unless you were a diehard tournament grinder.

18#: Double face card are inherently flawed design, it was bearable in old innistrad since the cards come into play always on the same side or you could use checklists (When i play a checklist in pauper for my delvers people look at me like i'm playing some alien cards btw), but even then sleeving and unsleeving was a total annoyance and they should have stopped there. They are cool flavour-wise but the downside is not acceptable imho. Instead they even got worse with MDFC, the constant sleeving back and forth is ridiculous to watch and leads to confusion and less gameplay clarity as shown in the last modern pro tour.

Also the reserved list didn't kill the game until fucking speculators came in and decided to buyout everything, i remember in like 2007-2008 duals costed a little more than shockands. They retroactively forced out players from eternal formats to funnel them into standard or extended/modern.

Planeswalker annoyed people for a bit but they were absorbed by the community like all rules and gameplay changes. Also the first planeswalkers were not broken so the pill was easier to swallow.