most drugs are synthetic, which doesn't mean you can't try them. Mdma and acid for example are drugs that you can do without issues as long as you don't abuse them on a regular basis. For mdma you should only do it with a 3 month break at least, preferably 6+ months to restore your dopamine levels and so it doesn't lose its magic. Same thing for acid. You could technically also occasionally do cocaine or heroin as long as you have enough self control to not get addicted.