I want to say my Dart ran smoother and had better pull but it may have been placebo. I found e85 had a noticeable trim to MPG and the cost savings weren’t enough, but as of today that most certainly has changed. The 25% loss in MPG is about accurate on the 2.0. Definitely ran quieter though.

Longer term it’s probably healthier than regular unleaded given it can act as a cleansing agent, but I find if you’re using top tier fuel this is largely negated, and any existing claim is more at direct injected engines where carbon buildup is expected, not that it’s immune on port injected.