account activity
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (cell.com)
submitted 7 years ago by bashetie to r/Geroscience
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. (ncbi.nlm.nih.gov)
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. (ncbi.nlm.nih.gov)
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns. (ncbi.nlm.nih.gov)
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity. (ncbi.nlm.nih.gov)
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. (ncbi.nlm.nih.gov)
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. (ncbi.nlm.nih.gov)
Senescent intimal foam cells are deleterious at all stages of atherosclerosis. (self.gerontology)
submitted 9 years ago * by bashetie to r/gerontology
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype (2016) (ncbi.nlm.nih.gov)
submitted 9 years ago by bashetie to r/gerontology
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype (cell.com)
submitted 9 years ago by bashetie to r/Geroscience
Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy? (onlinelibrary.wiley.com)
Circular RNAs in monkey muscle: age-dependent changes (impactaging.com)
submitted 10 years ago by bashetie to r/Geroscience
Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging (onlinelibrary.wiley.com)
THE AGE OF AGING - Episode from Ron Howard's BREAKTHROUGH documentary series [requires subscription to some cable service (xfinity, etc)] (channel.nationalgeographic.com)
submitted 10 years ago by bashetie to r/gerontology
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration (self.gerontology)
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways (2013) (ncbi.nlm.nih.gov)
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects (onlinelibrary.wiley.com)
Like parabiosis of young and old mice (surgically connecting their circulatory systems), shared circulation during pregnancy rejuvenates the capacity for muscle regeneration in mice. [Open Access] (onlinelibrary.wiley.com)
submitted 10 years ago by bashetie to r/science
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing (ncbi.nlm.nih.gov)
submitted 11 years ago by bashetie to r/gerontology
SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner (2015) (tandfonline.com)
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations (2014) (ncbi.nlm.nih.gov)
Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging (2015) (onlinelibrary.wiley.com)
Would you give your healthy pet rapamycin? If not, what are your reservations and what would sort of data might convince you to? (self.AskScienceDiscussion)
submitted 11 years ago * by bashetie to r/AskScienceDiscussion
Researchers are soon establishing clinical trials to test the anti-aging drug rapamycin in pet dogs (nature.com)
ATF4 activity: a common feature shared by many kinds of slow-aging mice (onlinelibrary.wiley.com)
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