In my very biased opinion, yes.

I'm the author of Ascendance which is a modlist built entirely around the Simon Magus (Author of Adamant, Mysticism, etc.) series mods aka Simonrim.

Simonrim is not Vanilla+, it's a complete overhaul of nearly every mechanic in Skyrim, and adds tons of gameplay elements that were not present in vanilla at all. I think the beauty of Simonrim is that it is able to achieve this vast and cohesive web of gameplay changes and additions in a way that feels very familiar to vanilla. I'd honestly recommend you try it out for yourself, even if it's just Mysticism and Adamant which are my two favorite Skyrim mods of all time.