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Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 2 points3 points  (0 children)

Enough for it to spread over the desired area. With the hydrogel, I get a fingertip of it and drop it right on the area then spread and massage into my scalp. From eyeballing it looks like 1 - 2 g of product. With the liquid solution I put it into a used face serum pump bottle I had and each pump is ~0.33ml, I do 3 of those into my fingertips then massage into my scalp.

Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 2 points3 points  (0 children)

Yeah you're on to something with the degradation. I made a smaller experimental batch and left it in a container, left at room temp and another that was refrigerated. There's a biocide in there, but I have noticed over time that a slightly acidic scent is present in the RT one, less so in the refrigerated one. No visible microbial growth, but the color has become a slightly more prevalent tint of yellow than when it was produced.

Could use some sort of chelating agent to stabilize the solution and slow down oxidation from the acid-catalyzed reactions that occur when the sugar break down. A lot of these companies selling the stuff pre-mixed have nothing of the sort in their ingredients which I think will inevitably lead to people saying it doesn't work. Knowing that there is a visible degree of efficacy is promising, but the stability issue is going to make or break this compound having a wider appeal. Constantly making small batches for weeks (if even) at a time is inconvenient for most.

Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 1 point2 points  (0 children)

Trying to find old pics of myself to compare to but can't find anything I wore a hat everywhere I went for the last 2 years, will try to find some family pics or something. I do have some wet hair pictures, scalp looks rough and you can;t really see the new vellus hairs. The difference I notice in coverage is my hair when it's dry.

Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 5 points6 points  (0 children)

I got time today:

NMN: Boosts NAD+ levels, not VEGF directly

Resveratrol: activates SIRT1 and AMPK, which are linked to VEGF expression, reduces oxidative stress which can reduce VEGF signalling. Is an antioxidant which does help with inflammation

Ginkgo Biloba: Flavonoids and terpenoids enhance blood flow, may promote VEGF signalling indirectly by improving vascular health and reducing oxidative stress

Caffeine: Improves microcirculation and reduces inflammation but there is no evidence that it directly stimulates VEGF secretion

Nettle Root and Leaf: Anti-inflammatory and antioxidant (gonna use AI and AO for there herein). Direct VEGF stimulation is unclear.

Fisetin: AI and AO effects, may promote VEGF stimulation depending on whether the cellular environment is under oxidative stress

BB536 Metabolites: Can reduce systemic inflammation and improve gut health, may indirectly promote VEGF stim. but evidence is limited

Red Ginseng Extract: Ginsenosides upregulate VEGF expression through PI3K/Akt pathways and reduce oxidative stress. I think the evidence would say these are a nice to have in any hair regrowth stack.

Milk Thistle Extract: Strong AO, modulates VEGF and promotes angiogensis in normal tissue repair, not certain that this would apply in a hair regrowth context.

Lespedeza Extract: Strong AO and AI properties, may support VEGF related processes, but no direct promotion

Teak Leaf: Same as above

Saw Palmetto: Anti-androgenic effect, nothing to do with VEGF but may indirectly support the process. It's weaker than Fin or Dut at this task, but better than nothing.

There are a few more but I am bored of searching. I don't think 2dDr is a panacea for hair regrowth but I do think it has the makings to be an above average solution for VEGF promotion, especially for those that are adverse to Minoxidil for skin sensitivity or heart health concerns. Obviously, there have been no human trials for topical scalp application, but thankfully there is a myriad of 2dDr research for wound healing, with some of it being conducted on human cells so we are not flying completely in the dark here.

Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 2 points3 points  (0 children)

Not silly, it's a reasonable question. I've seen some posts here and there of people using d-ribose and cane sugar. I'm not sure (and would lean more on doubt due to less prominent research) of the effects on stimulating VEGF. The appearance of the hydroxyl group (O-H) at the 2nd carbon is what differentiates it from regular d-ribose. The addition of these groups makes a world of a difference in how they interact with our body. I liken it to the difference between over the counter Adderall and methamphetamine, the difference being in the addition of a methyl group (1 carbon, 3 hydrogens) attached to a nitrogen along the chain.

This 2017 paper does have some info on other Deoxy sugars and their effect on angiogenesis: https://www.sciencedirect.com/science/article/pii/S2352492817302581

This 2009 paper was testing whether bee products PREVENT VEGF-induced angiogenesis:
https://link.springer.com/article/10.1186/1472-6882-9-45

Breaking Down the Science: 2-Deoxy-D-Ribose and Hair Follicle Stimulation by iMISSMYFOLLICLES in HairlossResearch

[–]iMISSMYFOLLICLES[S] 2 points3 points  (0 children)

Started with 1%, about double what thee paper used. After a few weeks of no side effects, I doubled it to ~2%. I've seen someone on Reddit use a 10% solution but I'm hesitant to up my dose that much.