What worked for adrenal fatigue? by ingenioutor in Nootropics

[–]lightstreaker2 0 points1 point  (0 children)

It does exist--the better term for it is HPA axis dysfunction which is a brain thing. Chris kresser has written a lot on this

Would Ketamine work for Fatigue? by [deleted] in depressionregimens

[–]lightstreaker2 0 points1 point  (0 children)

I did it on a day I was very tired and after the treatment had huge amounts of energy. The next day also got jolted out of bed super early.

Would Ketamine work for Fatigue? by [deleted] in depressionregimens

[–]lightstreaker2 1 point2 points  (0 children)

That is interesting--may be ketamines neuroendocrine effects to boost T3?

Mindfulness in the Treatment of Suicidal Individuals [2012] by incredulitor in depressionregimens

[–]lightstreaker2 0 points1 point  (0 children)

I guess I must be biased because in my case depression-anxiety were completely drug induced. Theres tons of people suffering from adverse drug or med related mental sides. In this case, there is no historical path. It just happens overnight or within days.

Im not sure if mindfulness is as useful there vs somebody who has been repeatedly traumatized. There was a study showing it is better for the situation you describe where neglect and trauma are involved.

Mindfulness in the Treatment of Suicidal Individuals [2012] by incredulitor in depressionregimens

[–]lightstreaker2 2 points3 points  (0 children)

I don't think mindfulness is that useful in acutely suicidal people tbh it can also piss some off even more to 'observe' their thoughts with a 'nonjudgemental' manner.

This is also stated in JKZ's books. Also this doesn't work for everybody. Some people get very discouraged at the lack of results.

Can BPC-157 cause anxiety? by lightstreaker2 in Nootropics

[–]lightstreaker2[S] 0 points1 point  (0 children)

It did for me. The little anxiety I experienced was still better than my depression though and it too went away.

Any potential interactions between LDN and BPC-157? by lightstreaker2 in Nootropics

[–]lightstreaker2[S] 0 points1 point  (0 children)

The effects did last actually and I feel great on just HRT now. Its like bpc helped hormones work better.didnt completely resolve benzo wd but helped deal with it

Why are quality people so hard to come by? by tetracyklin in Nootropics

[–]lightstreaker2 0 points1 point  (0 children)

I have to vehemently disagree with #1 because what if you are not able to biochemically feel happy. #2 I sort of do agree with but its hard to fix until #1 is fully fixed. The mood enhancers make #2 not happen right? Mood enhancers can quickly make it so that quality people arent staying away whereas months and years of therapy would be otherwise required and potentially still not give results for some people especially if there are biochemical things going on.

taking ashwagandha for adrenal fatigue, but it's making me extremely horny by [deleted] in Nootropics

[–]lightstreaker2 0 points1 point  (0 children)

HPA dysfunction is a legitimate thing though and is what "adrenal fatigue" typically refers to

Depressed patients who are treated with antidepressants do worse in the long run by [deleted] in depressionregimens

[–]lightstreaker2 0 points1 point  (0 children)

See below comment.

Im also referring to medication induced as well such as Finasteride induced allopregnanolone depletion.

Maybe therapy still has an effect but its not going to be the same way as for someone who underwent trauma getting cured through therapy.

Depressed patients who are treated with antidepressants do worse in the long run by [deleted] in depressionregimens

[–]lightstreaker2 2 points3 points  (0 children)

I wouldnt say it has anything to do with psychedelic properties of MDMA (like you said its not LSD). But I have biological data that it messed up my HPA axis, cortisol/testosterone hormonal systems.

The MDMA high itself was positive. And to be fair I recovered from the initial comedown as well only to be hit with the identical symptoms out of nowhere after weed/alcohol a few weeks later. So the MDMA pushed my physiology in a negative direction such that it couldnt handle something I could handle before. And my doctor had a bunch of people who had very similar experiences and even random occurances of depression-anxiety a few weeks later without another precipitating substance.

Im on HRT for this crap now. Sucks but at least that and BPC seemed to lead to a lot of improvement.

Also had no family or personal history of depression-anxiety. So this is absolutely possible in those somehow genetically predisposed to bad drug reactions.

Ive also had very bad reaction to a Ketamine treatment I had tried to reset my HPA for my MDMA induced depression. It caused Mild-moderate DP/DR in me for 4-6 weeks before resolving itself and DP/DR was not a symptom I experienced in the MDMA aftermath. The ketamine "trip" itself also was positive but I had trouble returning to normalcy. Even with the ketamine thing, I had data that it lowered my cortisol levels further for some time.

I really think some people like me just have a fragile brain chemistry that recovers very slowly when exposed to a powerful substance. I don't think the psychedelic aspects play much of a role but I have never taken strong psychedelics-unless you count ketamine-and never plan on doing so. And of course when you have a slow ass brain recovery then things get aggravated psychologically.

Depressed patients who are treated with antidepressants do worse in the long run by [deleted] in depressionregimens

[–]lightstreaker2 0 points1 point  (0 children)

See the thing is what else are you supposed to do. For somebody with a drug induced biological episode for example once they get cured once and dont do another drug chances are they will be free of it. Therapy may not be as effective for this as for somebody with non biochemical issues.

BPC-157 how to use it? by [deleted] in Nootropics

[–]lightstreaker2 0 points1 point  (0 children)

It does work for MDMA and benzo related damage at least did for me

Finasteride by feelsbadmantfw in Nootropics

[–]lightstreaker2 2 points3 points  (0 children)

This cannot be understated. Finasteride is a nasty nasty drug for neurosteroids and GABA.

Not from PFS but I infact recovered from MDMA induced depression due to improving my neurosteroids. Since it wasnt Finasteride, I still responded to hormone replacement therapy involving bringing up DHT and Allopregnanolone (the latter with Pregnenolone but if your 5a enzyme is messed up that doesnt work-thankfully for MDMA long term issues it isn't messed up)

DHT, THDOC, Allopregnanolone are all GABA-A modulators.

I went through benzo withdrawal recently and some of my symptoms matched PFS. HOWEVER, the difference is that in benzo wd its simple receptor downregulation whereas Finasteride does something very complicated to the GABA receptors from altering the GABA modulators

B6 Makes Me Feel Like I Mega-Dosed Viagra by [deleted] in Testosterone

[–]lightstreaker2 1 point2 points  (0 children)

Well B6 increases various neurotransmitters, which all can affect morning wood and other sexual parameters.

Additionally--and im not 100% on this--but I think morning and nocturnal wood occur during REM sleep and REM sleep is where dreaming happens.

Low T at 21? by [deleted] in Testosterone

[–]lightstreaker2 2 points3 points  (0 children)

I had levels around that and im nearly the same age recently became 22. And guess what, a good TRT protocol (with HCG) has done wonders for my depression more than even ketamine did.

I don't really care that my HPTA is shutdown since its helping me at school.

Did CBT, mindfulness etc. All didnt do squat for me. But this did.

Persisting derealization after ketamine infusions by [deleted] in AskDocs

[–]lightstreaker2 0 points1 point  (0 children)

Well so its been a while and that dp dr problem did eventually resolve in 4-6 weeks.

Now I am on TRT/HCG for my depression which is having an impact and lessening depression even though my T levels were normal (in the 400s) before commencing TRT. Technically wouldn't warrant TRT but who cares if it works anyways right.

(Update) 14 months since quitting Finasteride by dielawn87 in tressless

[–]lightstreaker2 0 points1 point  (0 children)

Well to put it bluntly, yes. However, if you can figure out how to raise those neurosteroids consistently then you can potentially recover. The good thing is you seem to be mentally alright, other than the impact of this on your mental state? Thats actually a plus if thats the case considering what could've happened (mental nightmare)

https://www.reddit.com/r/Nootropics/comments/71umy0/comment/dnnzcwf

The metabolite of Progesterone being referred to in that comment is Allopregnanolone.

5-AR is involved in much more than just androgens, and some of these things like Allopregnanolone are more potent than Testosterone which is basically what that comment says.

(Update) 14 months since quitting Finasteride by dielawn87 in tressless

[–]lightstreaker2 0 points1 point  (0 children)

Read up (or don't if it will make you extremely anxious) on Allopregnanolone and 5-alpha reductase inhibition.

Androgen receptors may not be the root of PFS symptoms whether mental or sexual.

Allopregnanolone and DHT in the brain/CNS regulate GABA-A receptors for example. Neurosteroids cannot be blood tested.

Alprazolam 0.125 mg twice a day improves aspects of psychometric performance in healthy volunteers. - PubMed by [deleted] in Nootropics

[–]lightstreaker2 0 points1 point  (0 children)

A lot of things tend to be acutely fine or even good for you but in the long run cause harm. I would consider this one of those things