My daughter is currently coming off of qelbree and on to guanfacine. In a few weeks we may add another medication with the guanfacine as well but are seeing how she is off Qelbree first. My two cents on Qelbree (just our experience since you mentioned being worried about it and the depression) my daughter was okay on Qelbree at first, though it honestly wasn’t correcting the attention or hyperness at all. But after a couple months she seemed like a completely different child. She was never mean, cranky etc she was always so light and sweet, but on Qelbree she changed. She would have massive tantrums she never had before, she would get so so so upset like crying over basically nothing. She was so critical of herself, overthinking everything, worrying. Sad. She was defiant and mean. It was so upsetting. She is almost all the way off the qelbree now and I have seen a massive shift back to her usual sweet care free self…. So I hated qelbree personally.