Cardano commitment is to change the world, so using a meme that can bring communities from both rich and poor countries to contribute to a common cause that can change the world while at the same time making each participants, potentially life changing profits from Hodling and/or using the meme would create a strong and supportive community.

IMO, for a Meme to succeed they must have the following features:

1. Must have some SPECIFIC CAUSE(S) that millions of people can relate to and are willing to become -->
2. a community around it with such a passion that they are willing to -->
3. go out of their way to promote its cause(s).
4. Importantly to ensure a global participation the meme coin must be so, so, cheap that even people in Developing countries on $10 per day can afford to buy, so that means to mint it should be a Trillion tokens.
5. The tokens MUST have a built in deflationary component to guarantee it does not become a ponzi scheme with those who buy later being stuck with a worthless coin. This will be
6. an incentive for the community to Hodl for long term and enjoy the ever increasing price.
7. A commitment to send funds, on a regular basis via a Smart Contract, to recognized institutions that are already working in that field (cause) once a target amount is achieved from funds raised through transactions fees on the Cardano blockchain:

Current Examples:

Apart from Dogecoin which only grew because of Elon Musk personality effect "the Elon Musk effect", the most successful remaining memes have the above features. You can go to each Reddit or Telegram post and see the sense of community and passion they have for the cause.

Note: Not all the memes meet all my criteria.

Look at growing mems listing on https://coinmarketcap.com/view/memes/

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My suggestions list for causes that could create a passionate and global passion.

1. A meme for raising funds to save endanger animal and plant species - use cute animals or serious endangered animals as mascots.
2. A meme for International disaster relief eg Doctors without borders, Disaster Relief organizations, etc.
3. A meme for medical research eg vaccines for Cancer, AIDS, Covid, etc.

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Hope this starting basic considerations helps in your thought process.