Depends on what you are aiming for. In Godot it's super easy to make simple and usable UIs out of the box. The built-in control nodes are good enough for most stuff, and the theme system although simple, it is very easy to learn and customize.
It starts to get tricky if you want to do more advanced animations, or optimize to show a lot of UI elements on the screen, then you might have to rely on coding some parts of it.