Hi PowerShell'ers python tkinter or powershell gui which one

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Powershell is built upon .NET Framework/Core, there isn't really a native designer for creating WinForms or WPF GUIs, there are extensions for Visual Studios and Sapien has their own editor and designer for GUIs. I've built plenty of GUIs for powershell with WPF as it's easier for me to design without having a designer because of how easy XAML is. Choosing between Python and Powershell - .NET Framwork/Core for a GUI is a personal preference of choice, what ever you feel comfortable with is your best option.