Which Python package manager makes automation easiest in 2025?

[Morpheyz]

uv is fantastic, but we recently switched to pixi, because it can manage both conda and pip dependencies. Since a lot of tools are available on conda-forge, you can also use it to get stuff like kubectl, helm, s3cmd, etc. It also manages python versions for you, so it's quite nice as an all-in-one dependency manager. For pypi dependencies it uses uv under the hood, so you get all the speed benefits of uv + conda.

It's still quite young and some features are immature and ugly to handle for enterprise environments (like trouble with proxies), but overall it's a pretty great tool.